Abstract: FR-PO0268
Plasma Proteomic Biomarkers Associated with Prevalent and Incident CKD in a Population-Based Cohort
Session Information
- CKD: Omics, Systemic Stressors, and Targeted Pharmacotherapy
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2201 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Svensson, Maria K., Uppsala Universitet, Uppsala, Uppsala County, Sweden
- Jeansson, Marie, Karolinska Institutet, Stockholm, Stockholm County, Sweden
Group or Team Name
- Jeansson Lab
Background
Chronic kidney disease (CKD) is a serious condition and a major public health concern that is often diagnosed only after substantial and potentially irreversible kidney damage has occurred. This study aimed to identify novel plasma protein biomarkers associated with CKD in a large population-based cohort using high-throughput proteomic profiling.
Methods
Within the population-based SIMPLER cohort, 12,314 participants underwent plasma proteomic profiling of 276 proteins. CKD was defined as either a clinical diagnosis (ICD-code) or an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. Associations between plasma biomarkers and both prevalent and incident CKD were assessed using weighted Cox regression models. The median age at baseline was 72 years, and the median follow-up time was 10.7 years.
Results
At baseline, only 2.8% of participants had a recorded clinical diagnosis of CKD, whereas inclusion of the eGFR criterion identified 21.6% as having CKD. Cross-sectional analyses revealed that 230 proteins were associated with increased odds of CKD, with odds ratios of up to 72.11, while 5 proteins were associated with lower odds of CKD. During follow-up, 72 biomarkers were associated with an increased risk of incident CKD, with hazard ratios of up to 2.63, whereas 1 biomarker was associated with a reduced risk.
Conclusion
CKD appears to be substantially underdiagnosed in this population-based cohort. Many of the identified proteins have previously been linked to CKD, while others may represent novel biomarkers. Ongoing analyses are evaluating whether these biomarkers are directly involved in disease mechanisms or primarily reflect reduced renal clearance.
Volcano plot for Cox model adjusted by age, sex, and eGFR for follow-up plasma proteins. Dashed horizontal line=Bonferroni adjusted significance.
Funding
- Private Foundation Support