Abstract: SA-PO0635
Hospitalizations for Cardiovascular Disease Among Middle-Aged and Older Adults with Lupus Nephritis and IgAN
Session Information
- Glomerular Diseases: Clinical, Outcomes, and Therapeutics Research - Other
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Sim, Jovan Sao Ang, Lee Kong Chian School of Medicine, Singapore, Singapore
- Hee Jin Veronica, Ng, Lee Kong Chian School of Medicine, Singapore, Singapore
- Tan, Hui Zhuan, Singapore General Hospital, Singapore, Singapore
- Lee, Tung Lin, Singapore General Hospital, Singapore, Singapore
- Mok, Irene Yanjia, Singapore General Hospital, Singapore, Singapore
- Choo Chon Jun, Jason, Singapore General Hospital, Singapore, Singapore
- Lim, Cynthia Ciwei, Singapore General Hospital, Singapore, Singapore
Background
Glomerulonephritis is increasingly diagnosed in older adults at increasd risk of cardiometabolic disease. We aimed to describe the prevalence of cardiovascular (CV) related hospitalizations among individuals with LN and IgAN who were 40 years and older and receiving immunosupressants at follow-up.
Methods
We performed a single-centre retrospective cohort study of individuals with biopsy-confirmed LN or IgAN diagnosed between Oct 2015 and Aug 2025. EMR data were extracted and recorded in REDCap as 6-monthly follow-up visits. Visits were included if patients were aged ≥40 years and receiving immunosuppressants at follow-up; visits with missing hospitalization data were excluded. The outcome was CV-related hospitalization within 6 months of each visit. Associated factors were assessed using mixed-effects logistic regression with random intercepts for patient and treatment year.
Results
We included 1,478 visits (1,119 LN; 359 IgAN) from 207 individuals between 28 Apr 2016 and 12 Feb 2026. Median follow-up was 30 months (IQR 12–54). At follow-up, median age was 53 years, eGFR 84 ml/min/1.73m2, UPCR 0.5 g/g and BMI 24.9 kg/m2. CV risk factors were common: hypertension 48.2%, hyperlipidemia 32.0% and diabetes 10.0%; prednisolone use was frequent (80.6%). CV-related hospitalizations occurred at 18 visits (1.2%), commonly for IHD or AMI, while other hospitalizations occurred at 302 visits (20.4%). CV hospitalization was independently associated with AKI (OR 3.62, 95% CI 1.49–8.84) and infection (OR 2.40, 95% CI 1.21–4.77) hospitalizations.
Conclusion
CV-related hospitalizations were infrequent during 6-monthly follow-up for LN and IgAN who were 40 years or older and treated with immunosuppressants and were associated with AKI and infection. However, the low event rate likely reduced the power to detect significant associations.
Acknowledgment
The authors thank the Renal Coordinator Unit and the Renal Diagnostic Unit of the Department of Renal Medicine, Singapore General Hospital for their support in the project.