Abstract: FR-PO0281
Low Physical Function Associated with Higher Risk of Incident Cognitive Impairment in Adults with CKD
Session Information
- CKD: Omics, Systemic Stressors, and Targeted Pharmacotherapy
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2201 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Campos, Sinead M., University of Illinois Chicago, Chicago, Illinois, United States
- Missikpode, Celestin, University of Illinois Chicago, Chicago, Illinois, United States
- Sara, Gordon, University of Illinois Chicago, Chicago, Illinois, United States
- Ricardo, Ana C., University of Illinois Chicago, Chicago, Illinois, United States
- Yaffe, Kristine, University of California San Francisco, San Francisco, California, United States
- Lash, James P., University of Illinois Chicago, Chicago, Illinois, United States
Group or Team Name
- CRIC Study Group
Background
Adults with chronic kidney disease (CKD) are at higher risk for cognitive impairment. Physical function, a modifiable marker of physiologic reserve, has been linked to cognitive impairment in the general population, but this association has not been examined in CKD.
Methods
Sample included 981 Chronic Renal Insufficiency Cohort participants with physical function assessment (Short Physical Performance Battery [SPPB]; gait speed, balance and chair stands) and ≥2 follow-up measures of cognitive function without cognitive impairment at study entry. SPPB categorized as low (0-6), intermediate (7-9) and high (10-12). Cognitive tests included Modified Mini-Mental (3MS, global cognition); Trails A (attention/processing); Trails B (executive function) and Buschke (verbal memory). Associations between SPPB and incident cognitive impairment (≥1 SD worse than cohort mean) were examined using Cox models.
Results
Mean age was 66.0 years, 45.4% were female, 62.6% had diabetes and 39.7% cardiovascular disease, mean eGFR was 53.5 ml/min/1.73m2. After median follow-up of 5.3 years, rates of incident cognitive impairment were 24.4, 39.2, 67.9, 35.9 per 1000 person-years, respectively for 3MS, Trails A, Trails B and Buschke. Multivariable results are in Table.
Conclusion
Lower physical function was associated with higher risk of incident cognitive impairment across multiple cognitive domains, suggesting physical function may help identify patients with CKD at higher risk for developing cognitive impairment.
| Test | SPPB Category | Events/n | Per-1000 person yrs | HR (95% CI) |
| 3MS | High (10-12) | 11/160 | 10.1 | Ref |
| Intermediate (7-9) | 53/423 | 22.1 | 1.54 (0.78, 3.04) | |
| Low (0-6) | 68/398 | 30.1 | 2.18 (1.08, 4.38) | |
| Trails A | High (10-12) | 12/115 | 21.7 | Ref |
| Intermediate (7-9) | 32/279 | 30.4 | 1.28 (0.63, 2.58) | |
| Low (0-6) | 52/248 | 61.8 | 2.53 (1.24, 5.19) | |
| Trails B | High (10-12) | 16/103 | 32.7 | Ref |
| Intermediate (7-9) | 65/261 | 68.6 | 1.72 (0.96, 3.06) | |
| Low (0-6) | 64/214 | 91.7 | 2.09 (1.13, 3.85) | |
| Buschke | High (10-12) | 12/102 | 23.5 | Ref |
| Intermediate (7-9) | 31/250 | 32.1 | 1.38 (0.60, 2.78) | |
| Low (0-6) | 36/212 | 49.8 | 2.15 (1.02, 4.53) |
Adjusted for center, age, sex, race, education, diabetes, HTN, CVD, smoking, alcohol BMI, eGFR, urine protein-to-creatinine ratio
Funding
- NIDDK Support