Abstract: SA-PO0288
AKI in Acute Medical Admissions: Incidence, Aetiology, and Short-Term Outcomes with Secondary Analysis of Cardiorenal Syndrome, January-March 2025
Session Information
- AKI: Epidemiology and Risk Factors
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Ahmed, Zeinab A E E, University College Cork, Cork, County Cork, Ireland
- Rasool, Mudassar, University College Cork, Cork, County Cork, Ireland
- Mirghani Ahmed, Mohammed, University College Cork, Cork, County Cork, Ireland
- Macilwraith, Peter Lago, University College Cork, Cork, County Cork, Ireland
- Ahmed, Adeel Rafi, University College Cork, Cork, County Cork, Ireland
Group or Team Name
- Cork University Hospital
Background
Acute kidney injury is a common presentation of acute medical admissions,associated with increased mortality and healthcare costs.the incidence,aetiological spectrum and short-term outcomes of AKI among unselected acute presentations in an Irish setting have not been systematically studied. CRS,classified using the Ronco2008 and AHA2019 framework,is a clinically important subset whose prevalence from AKI-first perspective remains poorly defined.Aim to determine AKI incidence and aetiological distribution,characterise 30-day mortality, and perform a secondary analysis of cardiorenal syndrome prevalence and phenotype within the AKI cohort.
Methods
A retrospective observational study of all new acute medical presentation to a tertiary care hospital over 3 month 3,000 admissions.Patient data were extracted from clinical handover documents and cross-referenced with the clinical information system.Patients on established renal replacement therapy were excluded.AKI was defined and staged using KDIGO2012 criteria and classified by dominant precipitating mechanism.CRS was identified by chart review and sub-classified as acute cardiorenal syndrome or sepsis-induced CRS
Results
Of 3,000 presentations,170 patients (5.7%) had confirmed AKI with a mean age of 73 years.Pre-renal AKI predominated (n=131, 77.1%),with sepsis (n=48, 28.2%) and cardiorenal aetiology (n=48, 28.2%)equally the most frequent subcategories,followed by hypovolaemia (n=26, 15.3%)and hepatorenal syndrome (n=9, 5.3%).Intrinsic renal disease accounted for 22 cases (12.9%)post-renal obstruction for 9 (5.3%).CRS was confirmed in 48 of 170 AKI patients (28.2%),comprising 35 cases of acute CRS and 13 of sepsis-induced CRS,the latter driven principally by urosepsis and lower respiratory tract infection.30 mortality was 7.7% (n=13), with the majority of deaths (n=9, 69%) occurring in patients with confirmed CRS.
Conclusion
This study provides the first systematic determination of AKI incidence,aetiology and short-term outcomes among unselected acute medical presentations at an Irish university hospital. An AKI incidence of 5.7% with CRS in over a quarter of affected patients represents a significant burden.Two distinct CRS phenotypes were identified with differing therapeutic implications.The concentration of mortality within the CRS subgroup supports development of integrated cardio-nephrology care pathway