Abstract: TH-PO1208
Clinical, Biochemical, and Radiological Characteristics of CKD-Mineral and Bone Disorder in Children with ESKD on Peritoneal Dialysis in Vietnam
Session Information
- Pediatric Nephrology: CV Health, CKD, AKI, Dialysis, Transplantation, and Health Services Research
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pediatric Nephrology
- 1800 Pediatric Nephrology
Authors
- Pham, Van Thi Bich, College of Health Sciences, VinUniversity, Ha Noi, Viet Nam
- Bui, Linh Phuong, College of Health Sciences, VinUniversity, Ha Noi, Viet Nam
- Nguyen, Huong Thu, Department of Nephrology and Dialysis, Vietnam National Children's Hospital, Ha Noi, Viet Nam
Background
Chronic kidney disease-mineral and bone disorder (CKD-MBD) is a major complication in children with end-stage kidney disease (ESKD), affecting bone health, growth, and cardiovascular outcomes. Evidence on CKD-MBD in Vietnamese children on peritoneal dialysis (PD) remains limited. This study described clinical, biochemical, radiological features and identified factors associated with bone involvement in this population.
Methods
A cross-sectional study was conducted in pediatric ESKD patients on PD at the Department of Nephrology and Dialysis, Vietnam National Children’s Hospital, from January 2025 to December 2025. Clinical bone features were defined by bone pain, bone deformities or fractures. We collected clinical data and mineral metabolism markers (including calcium, phosphorus, PTH, ALP, vitamin D), and plain radiographs to assess skeletal abnormalities and extra-skeletal calcifications. Multivariable regression analysis was used to identify factors associated with clinical bone manifestations.
Results
Among 105 children receiving PD, all met criteria for CKD-MBD. Bone pain was the most frequently reported symptom (17.1%), followed by bone deformities (9.5%) and fractures (2.9%). Biochemical disturbances were prominent, with elevated PTH (97.1%), hyperphosphatemia (71.4%), hypocalcemia (33.3%), and low vitamin D (40.0%), despite calcium and vitamin D supplementation. Radiologic evaluations showed skeletal abnormalities in about two-thirds of patients, predominantly late ossification (65.4%) and osteoporosis (48.7%); extra-skeletal calcification was uncommon (5.1%). Dialysis duration in months (OR = 1.025, 95% CI: 1.002 – 1.049, p = 0.031) and anemia (OR = 3.825, 95% CI: 1.211 – 12.078, p = 0.022) were identified as significant factors associated with clinical bone features in pediatric PD patients.
Conclusion
CKD-MBD was universal in children with ESKD on PD in this single-center study, with biochemical abnormalities more common than overt bone symptoms. Persistent hypocalcemia and vitamin D deficiency, together with frequent radiological changes, highlight the need for routine biochemical monitoring, and optimization of mineral metabolism management in pediatric PD patients. Longer dialysis duration and anemia were independently associated with clinical bone manifestations.