Abstract: SA-PO0300
Serum Albumin as a Predictor of Contrast-Associated AKI After Computerized Tomography with Contrast in a Tertiary Hospital
Session Information
- AKI: Epidemiology and Risk Factors
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Author
- Go, Jeremy Owen Gomez, Jose R. Reyes Memorial Medical Center, Manila, National Capital Region, Philippines
Background
Iodinated contrast is nephrotoxic causing contrast-associated acute kidney injury (CA-AKI) via epithelial toxicity, medullary hypoperfusion and tubular damage. No specific treatment exists thus prevention is essential. Hypoalbuminemia has been linked to AKI in critically ill and postoperative patients, and each 1 g/dL decrease in albumin increases AKI risk by 134%. This study aimed to determine the association between serum albumin levels and CA-AKI among adults undergoing CT scan with IV contrast at Jose R. Reyes Memorial Medical Center (JRRMMC).
Methods
This prospective cohort was conducted at JRRMMC from December 2024 to February 2025. Included were consenting adults (>18 years old) with baseline serum creatinine and albumin measurements who underwent contrast-imaging with repeat creatinine testing 48–72 hours post-scan. CA-AKI was defined using KDIGO criteria as an increase in serum creatinine of ≥0.5 mg/dL (≥44 µmol/L) or ≥25% from baseline in 48–72 hours after contrast exposure. Hypoalbuminemia was defined as serum albumin <35 g/L.
Results
Among 135 patients, 12 developed CA-AKI (9%). Mean age was 53.62 ± 13.7 years, with nearly equal sex distribution (68 males, 67 females). CA-AKI incidence did not significantly differ according to sex (p=0.563), service department (p=0.568), comorbidities, or CT imaging type (p=0.969). Mean baseline albumin was 31.68 ± 7.68 g/L. No significant difference was found between patients with CA-AKI (31.27 ± 8.65 g/L) and without CA-AKI (31.72 ± 7.62 g/L; p=0.845). Serum albumin showed very low non-significant correlation with post-contrast creatinine increase or eGFR decline (p=0.638 and p=0.886, respectively).
Conclusion
The incidence of CA-AKI at JRRMMC is at 9% (average rates of 2-15%). Baseline serum albumin levels were not significantly associated with development of CA-AKI among patients undergoing CT scan with IV contrast. Albumin likewise showed no significant correlation with post-contrast creatinine elevation or eGFR decline.
Acknowledgment
The author would like to acknowledge the contributions of his advisers - Dr. Ma. Christina P. Kaw and Dr. Neil Martin D. Sese.
Factors associated with contrast associated AKI
| Parameters | Crude odds ratio | 95% CI | p-value |
| Serum albumin | 0.9922 (reference) | 0.9178 to 1.0727 | 0.844 |
| Post-scan creatinine | 1.0123 | 1.0033 to 1.0215 | 0.008 |
| Post-scan eGFR | 0.9722 | 0.9544 to 0.9903 | 0.003 |
Unit increase in post-scan creatinine increase CA-AKI odds by 1.23%; unit decrease in post-scan eGFR decrease CA-AKI odds by 2.78%