Abstract: SA-PO1207
Late Recurrence of Renal Cell Cancer After Kidney Transplantation
Session Information
- Transplantation: Clinical - Complications, Pediatrics, and Multi-Organ Considerations
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Transplantation
- 2002 Transplantation: Clinical
Authors
- Mustafa, Muhammad Raza, Westchester Medical Center Health Network, Valhalla, New York, United States
- Singh, Nandita, Westchester Medical Center Health Network, Valhalla, New York, United States
- Glicklich, Daniel G., Westchester Medical Center Health Network, Valhalla, New York, United States
Introduction
We present a case of metastatic clear cell cancer of renal origin almost 6 years after bilateral nephrectomy.
Case Description
This is a 68-yr old AA male, ESRD due to hypertension, underwent a deceased donor renal transplant in June, 2023. His past medical history was significant for HTN, Prostate cancer treated with total prostatectomy and radiation therapy, Left knee replacement, Papillary cell Renal cancer s/p left nephrectomy in 2015 and right nephrectomy in August 2021 for hemorrhage. He also had neuroendocrine tumor of GI tract requiring resections in 2019 and 2020. His PET scans was negative in 2022. Repeat imaging studies including CT scans, MRI and PET done every year remained negative for recurrence. Patient underwent deceased donor renal transplant in June of 2023 from a 27-year-old donor with KDPI of 30%. Induction was with steroids and Simulect, patient had DGF , started on monthly Belatacept infusions due to suboptimal Cr. He did well and his serum Cr stabilized at 1.2 -1.5. In November 2025 he started having left knee pain. X rays showed Large lobulated mildly expansile lucent lesion within the distal diaphysis of the left femur. The lesion was biopsied and it showed poorly differentiated metastatic carcinoma with immunostaining results suggestive of a renal origin, likely clear cell cancer. Patient underwent distal femur resection and replacement.
Discussion
This case highlights the importance of continuous surveillance for renal cell cancers even after the primary source has been removed many years ago. Although tumor relapse can occur, most relapses occur within the first 5 years after nephrectomy. However, the modality and length of surveillance is not clear at this time.