Kidney Week

Abstract: PUB041

Effect of Serum Zinc and Selenium on Arterial Stiffness in Patients on Hemodialysis

Session Information

• Publication Only

Category: Cardiovascular-Kidney-Metabolic Health

• 602 Cardiovascular-Kidney-Metabolic Health: Clinical

Authors

• Knehtl, Masa, Univerzitetni Klinicni Center Maribor, Maribor, Administrative unit Maribor, Slovenia

Masa Knehtl

• Varda, Luka, Univerzitetni Klinicni Center Maribor, Maribor, Administrative unit Maribor, Slovenia

Luka Varda, DrMed

• Vreca, Nino, Univerzitetni Klinicni Center Maribor, Maribor, Administrative unit Maribor, Slovenia

Nino Vreca, MD

• Bevc, Sebastjan, Univerzitetni Klinicni Center Maribor, Maribor, Administrative unit Maribor, Slovenia

Sebastjan Bevc, MD, PhD

• Ekart, Robert, Univerzitetni Klinicni Center Maribor, Maribor, Administrative unit Maribor, Slovenia

Robert Ekart, MD, PhD

Background

Atherosclerosis is accelerated in hemodialysis patients. Trace elements, including zinc and selenium, are essential for antioxidant and anti-inflammatory mechanisms, which also play a role in atherosclerotic process. We examined the potential association between zinc and selenium and arterial stiffness in chronic hemodialysis patients.

Methods

Thirty-two chronic hemodialysis patients were enrolled in our single-centre cross-sectional study. Pulse wave analysis (PWA) and carotid–femoral pulse wave velocity (cfPWV; Spygmocor® Atcor Medical, Sydney, Australia) were performed before the mid-week dialysis session. Serum zinc and selenium values were measured by standard laboratory methods. Statistical analysis was performed using commercially available SPSS® (version 31.0, Chicago, IL, USA).

Results

Mean age of the patients was 64.4±15.7 years, and 20 were male. The majority of enrolled patients (90.6%) had hypertension and 28.1% had diabetes. Mean zinc value was 14.8±2.5 (range 9.8 to 20.1 mcmol/l); mean selenium value was 65.7±16.7 mcg/l (range 34.7 to 98.9 mcg/l). Mean cfPWV was 9.2±2.6 m/s (range 4.4 to 16.4 m/s). Mean pulse pressure (PP) value was 53.5±15.4 mm Hg (range 31.0 to 94.0 mm Hg). Mean augmentation pressure (AP) value was 17.0±10.4 mm Hg (range 3.0 to 49.0 mm Hg). Mean augmentation index (Aix) value was 30.5±13.2% (range 7.0 to 58.0%). Using Pearson or Spearman's correlation test, we found no correlation between serum zinc values and arterial stiffness parameters. However, there was a moderately strong negative correlation between selenium values and PP (r=-0.37, p= 0.043) and AP (ρ= -0.42, p=0.019). This association with PP (β=-0.365, p=0.043) and AP (β=-0.434, p=0.015) remained in univariate regression analysis as well. After adjusting for sex and age in multivariable linear regression analysis, selenium remained independently associated only with AP (β=-0.346; p=0.040).

Conclusion

Lower serum selenium levels were associated with less favorable PWA parameters, but we found no association with PWV.