Abstract: FR-PO0967
Kidney Biopsy During Pregnancy or the Postpartum Period
Session Information
- Women's Health and Kidney Diseases
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Women's Health and Kidney Diseases
- 2100 Women's Health and Kidney Diseases
Authors
- Batool, Aisha, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
- Arora, Alok, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
- Ozieh, Mukoso N., Medical College of Wisconsin, Milwaukee, Wisconsin, United States
- El-Meanawy, Ashraf, Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Background
This study evaluated whether performing kidney biopsy during pregnancy versus waiting until postpartum period influences long term kidney survival and maternal fetal outcomes.
Methods
22 year retrospective cohort study (January 2002 to November 2024), including women aged above 18 who underwent native kidney biopsy during pregnancy or within three months postpartum. Outcomes included kidney survival (time to dialysis), maternal and fetal outcomes, histopathology patterns, and biopsy related complications.
Results
13 women underwent biopsy during pregnancy and 16 postpartum across all trimesters. Lupus nephritis was the most common histopathologic diagnosis in both cohorts. Proteinuria was the predominant indication for biopsy. Biopsy findings during pregnancy led to management changes in ALL cases, including initiation of high dose corticosteroids, iatrogenic preterm delivery, or pregnancy termination when necessary. In contrast, only 50% of postpartum biopsies altered management. Long term kidney survival did not differ significantly.
Conclusion
Kidney biopsy during pregnancy demonstrated acceptable safety and yielded high diagnostic utility, directly influencing clinical management in all antenatal cases.
Baseline Characteristics
| Clinical Variables | Biopsy during pregnancy, n=13 | Biopsy postpartum, n=16 |
| Maternal Age | 30.4 | 27.7 |
| Race | Black (4) Hispanic (1) Non Hispanic White (8) | Black (11) Hispanic (3) Non Hispanic white (2) |
| Comorbidities | Chronic hypertension (9) Diabetes Mellitus (2) Pre-Eclampsia (4) Pre existing kidney disease (0) | Chronic hypertension (4) Diabetes Mellitus (2) Pre-Eclampsia (8) Pre existing kidney disease (2) |
| UPCR mg/mg < 3000 or > 3000 | < 3000 (7) > 3000 (6) | < 3000 (4) > 3000 (12) |
| e-GFR on the day of biopsy (ml/min) | <29 (1) 30-59 (7) >60 (5) | <29 (2) 30-59 (6) >60 (8) |
| Trimester of Biopsy | 1 (7) 2 (3) 3 (3) Postpartum (0) | 1 (0) 2 (0) 3 (0) Postpartum (16) |
| Biopsy week | 15.9 | NA |
Determinants of long term dialysis needs after kidney biopsy (pregnancy Vs postpartum)
Kaplan- Meier curve for Kidney Survival