Abstract: TH-PO1096
Clinicopathologic Spectrum of Kidney Disease in Pregnancy
Session Information
- Pathology and Lab Medicine
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Pathology and Lab Medicine
- 1700 Pathology and Lab Medicine
Authors
- Ijaz, Hamza, Arkana Laboratories, Little Rock, Arkansas, United States
- Caza, Tiffany, Arkana Laboratories, Little Rock, Arkansas, United States
- Cv, Malathi, Renopath Center for Renal and Urological Pathology Pvt Ltd, Chennai, TN, India
- Larsen, Christopher Patrick, Arkana Laboratories, Little Rock, Arkansas, United States
- Kurien, Anila Abraham, Renopath Center for Renal and Urological Pathology Pvt Ltd, Chennai, TN, India
Background
Kidney disease complicates 3-5% of pregnancies; however, the etiology is often unclear as biopsies are not commonly performed. This study aims to compare the clinical indications and diagnostic spectrum of kidney pathology in pregnancy and postpartum periods across two distinct healthcare settings (US and India).
Methods
We identified kidney biopsies from pregnant and early post-partum patients from Arkana Laboratories (USA) and Renopath Center for Renal and Urological Pathology (India). A total of 542 biopsies (394 pregnancy, 148 post-partum) were identified from 134,575 native cases in the US cohort (0.4%), with 221 (28 pregnancy, 193 post-partum) of 51,971 in the Indian cohort (0.4%). Clinical and pathologic data were reviewed, including laboratory values, biopsy indication, and diagnoses. Chi Square testing was performed for statistics.
Results
Pregnant patients biopsied in India were younger (25.9 ± 4.5 vs 31.4 ± 7.4 years) with higher serum creatinine than in the US cohort (mean 1.9 ± 2.2 vs. 3.79 ± 2.45 mg/dL, p<0.001). Post-partum creatinine has higher in both cohorts than in pregnancy (Table 1). Proteinuria was the predominant indication during pregnancy (71.4% India, 57.4% US). Post-partum acute kidney injury predominated in the Indian cohort (80.3% vs. 16.2%, p<0.001), while proteinuria did for the US cohort (50.7% vs.11.9%, p<0.001).
Glomerular diseases were the most common diagnoses in both cohorts, particularly FSGS, IgA nephropathy, and membranous nephropathy (Table 1). Vascular insults were more often seen post-partum in Indian patients, including thrombotic microangiopathy (42.0% India vs. 14.2% US, p = <0.001) and cortical infarcts (10.9% vs. 1.4%, p=0.003, Table 1).
Conclusion
A large spectrum of diagnoses were identified during pregnancy and the post-partum period, demonstrating the importance of kidney biopsies for definitive diagnosis and disease management.