Abstract: SA-PO0521
Joint Trajectories of Body Mass Index and Waist-to-Hip Ratio and Cardiovascular Outcomes in CKD: Result from the KNOW-CKD Study
Session Information
- CKD: Clinical - Therapies, CKM Health, Special Populations, and More
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2202 CKD (Non-Dialysis): Clinical, Outcomes, and Trials
Authors
- Oh, Yun Jung, H Plus Yangji Hospital, Gwanak-gu, Seoul, Korea (the Republic of)
- Oh, Kook-Hwan, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea (the Republic of)
- Chung, Wookyung, Gachon University Gil Medical Center, Namdong-gu, Incheon, Korea (the Republic of)
- Jung, Ji Yong, Gachon University Gil Medical Center, Namdong-gu, Incheon, Korea (the Republic of)
Background
Body mass index (BMI) and waist-to-hip ratio (WHR) are important cardiovascular risk indicators in chronic kidney disease (CKD). However, the prognostic significance of their longitudinal joint patterns, rather than single time point measurements or individual alone, remains unclear. We investigated whether distinct concurrent trajectories of BMI and WHR are associated with differential cardiovascular outcomes in patient with CKD.
Methods
We analyzed 1,944 participants from the Korean Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD). Distinct joint trajectories of BMI and WHR were identified using multivariate group-based trajectory modeling, and the associations between trajectory groups and cardiovascular outcomes were investigated using Cox regression models.
Results
Five distinct joint BMI-WHR trajectory groups were identified; moderate-stable, low-increasing, high-decreasing, decreasing BMI with persistent high WHR, and increasing BMI with persistent high WHR. In Kaplan-Meir analyses, low-increasing group showed the lowest risk of cardiovascular outcomes, whereas increasing BMI with persistent high WHR group showed the highest risk (log-rank P<0.001). In multivariable-adjusted Cox regression analyses, the increasing BMI with persistent high WHR group showed significantly higher risk than all other trajectory groups.
Conclusion
Joint BMI-WHR trajectory patterns were significantly associated with cardiovascular outcomes. Individuals with persistently elevated WHR despite relatively low BMI trajectories exhibited the highest cardiovascular risk, suggesting that central adiposity may confer greater prognostic significance than generalized obesity. Longitudinal assessment of WHR in addition to BMI may improve risk stratification.
Funding
- Government Support – Non-U.S.