Kidney Week

Abstract: TH-PO1010

Post-Transplant Proteinuria Reduction Is Linked to Blood Pressure Improvement but Not Native Kidney Perfusion

Session Information

• Transplantation: Clinical - Outcomes, Malignancy, and Pathology
  October 22, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Transplantation

• 2002 Transplantation: Clinical

Authors

• Kannenkeril, Dennis, Universitatsklinikum Erlangen Medizinische Klinik 4 Nephrologie und Hypertensiologie, Erlangen, BY, Germany

Dennis Kannenkeril, MD

• Kliem, Thorsten, Universitatsklinikum Erlangen Medizinische Klinik 4 Nephrologie und Hypertensiologie, Erlangen, BY, Germany

Thorsten Kliem, MD, DrMed

• Heller, Katharina M., Universitatsklinikum Erlangen Medizinische Klinik 4 Nephrologie und Hypertensiologie, Erlangen, BY, Germany

Katharina M. Heller, MD

• Bytyqi, Venera, Universitatsklinikum Erlangen Medizinische Klinik 4 Nephrologie und Hypertensiologie, Erlangen, BY, Germany

Venera Bytyqi, MD

• Striepe, Kristina, Universitatsklinikum Erlangen Medizinische Klinik 4 Nephrologie und Hypertensiologie, Erlangen, BY, Germany

Kristina Striepe, MD

• Bosch, Agnes, Universitatsklinikum Erlangen Medizinische Klinik 4 Nephrologie und Hypertensiologie, Erlangen, BY, Germany

Agnes Bosch, MD

• Martirosian, Petros, University Hospital of Tübingen, Tübingen, Germany

Petros Martirosian, PhD

• Janka, Rolf, Universitatsklinikum Erlangen Radiologisches Institut, Erlangen, BY, Germany

Rolf Janka

• Uder, Michael, Universitatsklinikum Erlangen Radiologisches Institut, Erlangen, BY, Germany

Michael Uder, MD

• Schmieder, Roland E., Universitatsklinikum Erlangen Medizinische Klinik 4 Nephrologie und Hypertensiologie, Erlangen, BY, Germany

Roland E. Schmieder, MD, FASN

• Schiffer, Mario, Universitatsklinikum Erlangen Medizinische Klinik 4 Nephrologie und Hypertensiologie, Erlangen, BY, Germany

Mario Schiffer, MD, MBA

Background

An independent association between post-transplant proteinuria and cardiovascular risk was reported. In this study changes in proteinuria, renal perfusion of native kidneys and blood pressure were analyzed in patients following kidney transplantation (KTx).

Methods

Renal function (estimated glomerular filtration rate (eGFR), urinary albumin creatinine ratio (UACR)) and office blood pressure were assessed in patients with end-stage kidney stage of our living donor KTx program before and 2 months after KTx. Renal perfusion of the native kidneys was assessed in a sub-group of patients (n=14) using the arterial spin labeling MRI (ASL-MRI).

Results

The mean age of forty-two patients was 44.5 ± 14.8 years. eGFR at two months post-transplantation was 49.3 ± 15.2 ml/min/1.73 m². Two months after KTx a relevant fall in UACR (2103.5 ± 2727.0 mg/g creatinine vs. 87.1 ± 109.9 mg/g creatinine; p < 0.001), office systolic blood pressure (136.7 ± 19.8 mmHg vs. 123.5 ± 12.3 mmHg; p < 0.001) and office diastolic blood pressure (85.3 ± 11.6 mmHg vs. 78.3 ± 9.5 mmHg; p < 0.001) were noticed compared to before KTx. A correlation was found between reduction in UACR and reduction in systolic blood pressure (r=0.446, p=0.009). A significant decrease of the perfusion of native kidneys was determined after KTx (table 1). No association was found between decrease of the perfusion of native kidneys and reduction in UACR after KTx.

Conclusion

Reduction in proteinuria following KTx was associated with reduction in blood pressure, but not with decrease in perfusion of the recipient native kidneys.

table 1