Kidney Week

Abstract: PUB186

Energy-Adjusted Dietary Inflammatory Index and Malnutrition-Related Outcomes in CKD and Dialysis: A Systematic Review and Meta-Analysis

Session Information

• Publication Only

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Balaban-Barta, Serap, Gaziantep Universitesi, Gaziantep, Turkey

Serap Balaban-Barta, PhD

• Arslan, Felemez, Istanbul Bakirkoy Dr Sadi Konuk Egitim ve Arastirma Hastanesi, Istanbul, Turkey

Felemez Arslan, MD

• Campoverde, Clara, Universidad de Cuenca, Cuenca, Azuay, Ecuador

Clara Campoverde, MD

• Soto Sanchez, Alfredo Hiram, Hospital Poliplaza Medica, Ciudad Juarez, Chih., Mexico

Alfredo Hiram Soto Sanchez, MD

• Toh, Zhi Hui, University of Dundee, Dundee, Scotland, United Kingdom

Zhi Hui Toh

Background

Inflammation and nutritional wasting are common in CKD and dialysis. We examined whether higher energy-adjusted Dietary Inflammatory Index (E-DII) is associated with malnutrition-related outcomes.

Methods

PubMed/MEDLINE, Embase, Scopus, Web of Science, and Cochrane Library were searched for adult CKD or dialysis studies reporting E-DII/residual energy-adjusted DII with malnutrition, PEW, or sarcopenia. Odds ratios (ORs) were pooled using Hartung–Knapp random-effects models.

Results

Four cross-sectional studies were included (n=666): HD (n=291), PD (n=147), and non-dialysis CKD (n=228). In the primary highest-vs-lowest E-DII analysis (k=3), higher E-DII showed directionally higher but imprecise odds of malnutrition-related outcomes (OR 1.87, 95% CI 0.18–19.86; I²=62.2%). Sensitivity analysis including a derived sarcopenia contrast (k=4) yielded OR 2.14 (95% CI 0.66–6.95; I²=44.4%). Per 1-unit E-DII increase, pooled OR was 1.31 (95% CI 0.80–2.12; I²=38.1%).

Conclusion

Higher dietary inflammatory potential may be associated with nutritional wasting in CKD and dialysis, but current evidence is limited and cross-sectional. Prospective studies are needed.