Abstract: SA-PO0407
Cardiorenal Complexity of Anemia: Data from CARDIOREN
Session Information
- CKM: Clinical - Epidemiology and Outcomes
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Cardiovascular-Kidney-Metabolic Health
- 602 Cardiovascular-Kidney-Metabolic Health: Clinical
Authors
- Nunez-Delgado, Sara, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain
- Mendez-Fernandez, Ana Belén, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain
- Azancot, María, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain
- Gorriz, Jose L., Fundacion para la Investigacion del Hospital Clinico de la Comunitat Valenciana, Valencia, Spain
- Nuñez, Julio, Hospital Clínico Universitario de Valencia, Universitat de València, Valencia, Spain
- Soler, Maria Jose, Hospital Universitari Vall d'Hebron, Barcelona, CT, Spain
Group or Team Name
- CARDIOREN
Background
Anemia and iron deficit(ID) are worse predictors in heart failure(HF), but in cardiorenal syndrome(CRS) it was not reported. The objective is to investigate their impact in CRS.
Methods
Prospective study of the CARDIOREN cohort, comprising HF patients from 13 centers. Anemia and ID were described. Follow-up was conducted for 12 months or the occurrence of a composite endpoint(death, hospitalization, worsening HF or a ≥50% decline in eGFR).
Results
Of 1106 patients, 73%(808) had CRS. Anemia was present in 30.1% and ID in 47.9%(ESC2023 criteria), and 34.3%(KDIGO2026 criteria). CRS increased the prevalence of anemia(92.8%vs.69.5%;p<0.001). In a multivariate analysis, anemia was associated with HFpEF(OR2.06,95%CI:1.24–3.45), albumin(OR0.40,95%CI:0.27–0.58), transferrin saturation index(OR0.98,95%CI:0.96–0.99), creatinine(OR1.89,95%CI:1.42–2.55), and log(NT-proBNP)(OR1.33,95%CI:1.15–1.55)[Table1].
During follow-up, 266 patients experienced an event(236 patients with CRS). Anemia was associated with the endpoint in patients without CRS(HR1.75;95%CI:1.34–2.29) and with CRS(HR2.10;95%CI:1.61–2.74). ID was not associated with events in patients without CRS(ESC2023 HR0.60,95%CI:0.24–1.48; KDIGO2026 HR0.64,95%CI:0.21–1.91) but it was with CRS(ESC2023 HR1.43,95%CI:1.09–1.87; KDIGO2026 HR1.32, 95%CI:1.00–1.72), with a moderate predictive ability(C-index: anemia 0.65; ESC2023 0.59; KDIGO2026 0.58)[Figure1].
Conclusion
Anemia and ID are associated with poorer outcomes in patients with CRS, but with moderate predictive power, suggesting the need for specific definitions to stratify risk.
Funding
- Government Support – Non-U.S.