Abstract: FR-PO0406
Contrast-Induced Nephropathy: A Prospective Comparative Study Using Capillary Blood Sampling with Point-of-Care Creatinine Measurement
Session Information
- AKI: Biomarkers, Diagnostics, and Risk Prediction
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical, Outcomes, and Trials
Authors
- Lee, Tae won, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, Korea (the Republic of)
- Chang, Se-Ho, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, Korea (the Republic of)
- Jung, Sehyun, Gyeongsang National University Hospital, Jinju-si, Gyeongsangnam-do, Korea (the Republic of)
- Park, Dong Jun, Gyeongsang National University, Jinju-si, Gyeongsangnam-do, Korea (the Republic of)
Background
Contrast-induced nephropathy (CIN) is a significant cause of acute kidney injury but is often underdiagnosed due to procedural constraints. This study aimed to evaluate whether capillary blood sampling using a point-of-care testing (POCT) device can effectively diagnose CIN compared to conventional laboratory venous blood analysis.
Methods
This single-center, prospective observational study included 400 adults with chronic kidney disease (CKD) hospitalized at Gyeongsang National University Changwon Hospital from July 2024 to June 2025. Participants underwent contrast media exposure via CT or CAG. Creatinine levels were measured using both capillary (StatSensor) and venous blood at multiple time points (pre-exposure and 24–48 hours post-exposure). CIN was defined as an increase in creatinine ≥0.5 mg/dL or ≥25% from baseline.
Results
A total of 400 patients with chronic kidney disease (CKD) were enrolled in this prospective study. The study population had a mean age of 74.8 ±11.8 years in the No-CIN group and 69.2 ± 14.1 years in the CIN group, showing a statistically significant difference (p=0.008). Based on the gold-standard laboratory venous creatinine criteria, the overall prevalence of contrast-induced nephropathy (CIN) was 13.3% (53/400). When categorized by the mode of contrast exposure, patients undergoing coronary angiography (CAG) exhibited a significantly higher incidence of CIN (16.8%, 31/185) compared to those undergoing computed tomography (CT) (10.2%, 22/215; p=0.042).
Multivariate logistic regression analysis was performed to identify independent predictors of CIN. After adjusting for baseline clinical variables, five factors remained significantly associated with an increased risk of CIN: advanced age (OR 1.82, 95% CI 1.10–3.02, p=0.019), diabetes mellitus (OR 2.15, 95% CI 1.25–3.70, p=0.005), the use of ARBs (OR 2.48, 95% CI 1.35–4.56, p=0.003), and the administration of inotropic agents (OR 4.12, 95% CI 2.05–8.28, p<0.001). Additionally, the use of metformin was found to be a significant risk factor (OR 1.95, 95% CI 1.15–3.32, p=0.012).
Conclusion
Capillary POCT creatinine measurement shows excellent correlation with laboratory data and serves as a rapid, convenient tool for CIN diagnosis. This approach offers significant potential for the early detection and management of AKI in high-risk patients following contrast media exposure.