Abstract: SA-PO0818
Systemic Lupus Erythematosus Coexisting with IgAN: Case Series and Literature Review
Session Information
- Glomerular Diseases: Management, Evolving Strategies, and Practice-Changing Advances
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Sun, Xuejuan, The First Affiliated Hospital of Xiamen University, Xiamen, China
- Li, Yinan, The First Affiliated Hospital of Xiamen University, Xiamen, China
- Shao, Leping, The First Affiliated Hospital of Xiamen University, Xiamen, China
Background
Systemic lupus erythematosus (SLE) and Immunoglobulin A nephropathy (IgAN) are both autoimmune diseases, but exhibit distinct pathogenic mechanisms. Globally reported cases of SLE coexisting with IgAN remain sparsely documented.
Methods
This study comprehensively reviews all available cases through a systematic literature review spanning from 1995 to 2025. After excluding early cases with unavailable data, the final cohort comprises 16 cases, including 15 published cases and one novel case from our center. All cases meeting SLE diagnostic criteria with renal pathology demonstrating predominant IgA mesangial deposits and absence of classic lupus nephritis (LN) features.
Results
Renal manifestations included hematuria (16/16), proteinuria (15/16), sterile pyuria (6/16), granular casts (8/16), and renal dysfunction (4/16). Glucocorticoids were frequently used despite limited support for monotherapy in current IgAN guidelines.
Conclusion
In SLE patients with renal injury, LN is not the sole etiology, particularly in Asia-Pacific regions where IgAN is prevalent. Repeat renal biopsy may be needed when IgAN is masked by LN or appears after lupus control. Treatment should consider the activity of both diseases.
Acknowledgment
We are grateful to all participants, the doctors, and nurses of the Nephrology department for their efforts and contributions to this research.