Abstract: FR-PO0234
Mechanism of Periodontal Remodelling in CKD
Session Information
- CKD: Mechanisms of Injury and Fibrosis - 2
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2203 CKD (Non-Dialysis): Mechanisms
Authors
- Merckelbach, Erik, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, NRW, Germany
- Jankowski, Joachim, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany
- Noels, Heidi, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, Germany
- Jankowski, Vera, Rheinisch-Westfalische Technische Hochschule Aachen, Aachen, NRW, Germany
Background
Despite the high prevalence of periodontal remodelling in CKD patients, the underlying mechanism of the renal-periodontal crosstalk is poorly researched, with no driving mediators and pathways being identified. Thus, the goal of this study was to identify signalling pathways involved in periodontal remodelling and affected by CKD.
Methods
CKD was induced in DBA/2J mice for 12 weeks via an adenine-rich and high-phosphate diet. Afterwards, the mice were sacrificed, and mandibles and maxilla were collected for structural and pathways analysis.
Results
Adenine-fed mice showed an increased urea and creatinine retention in plasma, proving loss of renal functions. Micro-CT scan and histology analysis revealed extensive periodontal remodelling in the adenine-fed mice, including loss of alveolar bone, widening of the periodontal ligament, narrowing of tooth pulp canals, and enamel deterioration; all in line with clinical manifestations in CKD patients.
Investigation of the cause behind the pathophysiological remodelling revealed significant changes in kinase activity related to bone turnover.
Conclusion
In conclusion, renal impairments in DBA/2J mice fed with an adenine-rich diet led to clear signs of CKD-induced periodontal remodelling in line with clinical manifestations in human CKD patients. We were able to find hallmark mediators affected by the renal impairments that led to the pathophysiological remodelling of the periodontium, giving a better understanding of the mechanistic of the renal-periodontal crosstalk.