Kidney Week

Abstract: SA-PO1041

Intradialytic Dynamics of Upper Body Blood Flow (UBBF) and UBBF-Derived Cardiac Power Output in Patients on Hemodialysis with Central Venous Catheter as Vascular Access

Session Information

• Hemodialysis: Risk Factors, Epidemiology, and Outcomes
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Dialysis

• 801 Dialysis: Hemodialysis and Frequent Dialysis

Authors

• Yueh, Sheng-Han, Renal Research Institute, New York, New York, United States

Sheng-Han Yueh, MS

• Usvyat, Len A., Renal Research Institute, New York, New York, United States

Len A. Usvyat, PhD, FASN

• Kotanko, Peter, Renal Research Institute, New York, New York, United States

Peter Kotanko, MD, FASN

• Zhang, Hanjie, Renal Research Institute, New York, New York, United States

Hanjie Zhang, PhD

Background

With continuous monitoring by Crit-Line (Fresenius Medical Care, Waltham, MA), high-frequency intradialytic data enable tracking of the full trajectory of hemodynamic parameters. Characterizing these temporal patterns is critical, as dynamic changes during hemodialysis may reveal periods of heightened cardiovascular stress that are not captured otherwise. Estimated upper body blood flow (eUBBF) provides a flow-based assessment of circulation, while cardiac power output derived from eUBBF (CPO_eUBBF) integrates both flow and arterial pressure, reflecting cardiac performance. This study explored intradialytic trends of eUBBF and CPO_eUBBF.

Methods

Data was collected on April 26, 2022. We included 1,398 patients with central venous catheters (CVC) as vascular access and dialysis sessions lasting ≥ 3 hours. Central venous oxygen saturation (ScvO₂) was continuously recorded every 10 seconds using Crit-Line. eUBBF (L/min) was computed as described previously (Rosales L, et al., Blood Purif. 2019). CPO_eUBBF (in Watts) was calculated as eUBBF × mean arterial pressure (mmHg) / 451. Median values at each time point were visualized with LOESS smoothing.

Results

Both eUBBF and CPO_eUBBF declined progressively during dialysis by 12% and 17%, respectively. eUBBF showed biphasic change with a gradual reduction early into the treatment and an accelerated drop in the second half. CPO_eUBBF showed a more steady decrease.

Conclusion

Intradialytic eUBBF and CPO_eUBBF decline progressively. Continuous monitoring of eUBBF and CPO_eUBBF can provide real-time, point-of-care assessment of intradialytic hemodynamics. Future work will evaluate the association between dynamics of eUBBF and COP_eUBBF and clinical outcomes.

Acknowledgment

Artificial intelligence tools were used to assist in the writing of this abstract. The authors reviewed and edited the content and take full responsibility for the final version.

Funding

• Commercial Support – Fresenius Medical Care