Kidney Week

Abstract: TH-PO1227

Association of Anthropometric Indices with Glomerular Hyperfiltration in US Adolescents: An NHANES Analysis

Session Information

• Pediatric Nephrology: CV Health, CKD, AKI, Dialysis, Transplantation, and Health Services Research
  October 22, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Pediatric Nephrology

• 1800 Pediatric Nephrology

Authors

• Abdullah, Mahie Mozib, Cohen Children's Medical Center, New Hyde Park, New York, United States

Mahie Mozib Abdullah

• Frank, Rachel, Cohen Children's Medical Center, New Hyde Park, New York, United States

Rachel Frank, CNN, RN

• Shen, Carol L., Cohen Children's Medical Center, New Hyde Park, New York, United States

Carol L. Shen, MD

• Basalely, Abby Miriam, Cohen Children's Medical Center, New Hyde Park, New York, United States

Abby Miriam Basalely, MD, MS

• Castellanos, Laura J., Cohen Children's Medical Center, New Hyde Park, New York, United States

Laura J. Castellanos, MD

• Sethna, Christine B., Cohen Children's Medical Center, New Hyde Park, New York, United States

Christine B. Sethna, MD, MEd

Background

Glomerular hyperfiltration is an early marker of kidney dysfunction associated with obesity and cardiometabolic disease. Traditional measures such as body mass index (BMI) may inadequately capture metabolically adverse body composition. This study evaluated the association and discriminatory performance of anthropometric indices for identifying hyperfiltration in U.S. adolescents.

Methods

This cross-sectional study analyzed participants aged 12–19 years from the 2009–2018 National Health and Nutrition Examination Survey cycles. Hyperfiltration was defined as estimated glomerular filtration rate (eGFR-U25) ≥135 mL/min/1.73m². Anthropometric indices included BMI, waist-to-height ratio (WHtR), weight-adjusted waist index (WWI), A Body Shape Index (ABSI), and Body Roundness Index (BRI). Survey-weighted logistic regression models evaluated adjusted associations between standardized anthropometric indices and hyperfiltration. Models adjusted for age, sex, race/ethnicity, poverty-income ratio, caloric intake, and serum uric acid. ROC and sex-stratified analyses were also performed.

Results

Among 4,755 adolescents (15.41±0.05 years, 51.8% male), ABSI demonstrated the strongest association with hyperfiltration (OR 2.29, 95% CI 1.84–2.86), while BMI demonstrated the weakest association (OR 1.67, 95% CI 1.39–2.00) (Table). ABSI exhibited the highest discriminatory performance (AUC 0.721), followed by WWI (AUC 0.667). In sex-stratified analyses, ABSI remained strongly associated with hyperfiltration among females (OR 2.30, 95% CI 1.58–3.35), while BMI was not significant.

Conclusion

Novel anthropometric indices, particularly ABSI and WWI, demonstrated stronger associations and superior discrimination for glomerular hyperfiltration compared with BMI. These findings suggest that body shape and central adiposity may better reflect early kidney hemodynamic alterations than overall body mass in adolescents, particularly among females.

Adjusted Logistic Regression Models Between Anthropometric Indices and Glomerular Hyperfiltration

Odds ratios represent odds per 1 SD increase in each anthropometric index.