Kidney Week

Abstract: SA-PO0839

Long-Term Kidney Outcomes and Prognostic Determinants in Pure Class V Lupus Nephritis

Session Information

• Glomerular Diseases: Management, Evolving Strategies, and Practice-Changing Advances
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Glomerular Diseases

• 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics

Authors

• Mohammed Salman, Naurin Naim, King Saud University, Riyadh, Riyadh Province, Saudi Arabia

Naurin Naim Mohammed Salman, MBBS

• Alghanaym, Abdulaziz Abdulkareem, King Saud University, Riyadh, Riyadh Province, Saudi Arabia

Abdulaziz Abdulkareem Alghanaym, MBBS

• Alotaibi, Daad Abdulrahman, King Saud University, Riyadh, Riyadh Province, Saudi Arabia

Daad Abdulrahman Alotaibi, MD

• Alsuhaibani, Mohammad, King Saud University, Riyadh, Riyadh Province, Saudi Arabia

Mohammad Alsuhaibani, MD, MBBS

• Abdulkareem, Alsuwaida, King Saud University, Riyadh, Riyadh Province, Saudi Arabia

Alsuwaida Abdulkareem, MS, MSc, FASN

Background

In patients with pure Class V lupus nephritis (LN) presenting, a triple therapy has been recommended by most of guidelines. However, data examining the long-term renal outcomes and prognostic determinants in this population remain limited.

Methods

We conducted a retrospective cohort study of patients with biopsy-proven Class V lupus nephritis diagnosed between 2000 and 2025. The primary outcome was worsening renal function, defined as a doubling of serum creatinine. Baseline clinical and laboratory characteristics were analysed to identify factors associated with renal outcomes.

Results

A total of 37 patients were included in the study; 31 (78.9%) were female, with a mean age of 27.1 years. The median follow-up duration was 12 years (IQR, 8-15 years). During follow-up, 8 patients (21.6%) experienced worsening renal function, of whom 5 patients (13.5%) progressed to renal replacement therapy. Patients who developed adverse renal outcomes had a significantly higher baseline serum creatinine (mean +/- sd: 106.3 +/- 77.7µmol/L) compared with those who maintained stable renal function (mean +/- sd; 76.4 +/- 31.7µmol/L). Patients with baseline proteinuria ≥3.5 g/day demonstrated the highest rate of renal function deterioration. Notably, none of the patients with baseline proteinuria ≤1.5 g/day experienced worsening renal function during follow-up.

Conclusion

In this cohort with long-term follow-up of patients with pure Class V lupus nephritis, impaired renal function at presentation and baseline proteinuria >1.5 g/day were significant predictors of renal function deterioration.