Abstract: TH-PO0449
Schistosomiasis-Associated Glomerulopathies: Localization of the Schistosomiasis Antigen by Immunohistochemistry
Session Information
- Glomerular Diseases: Autoimmune Diseases
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1401 Glomerular Diseases: Mechanisms, including Podocyte Biology
Authors
- Sousa Pontes, Irma Bandeira de, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, SP, Brazil
- Braga Barbosa, Gessica Sabrine, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, SP, Brazil
- Dias, Cristiane B., Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, São Paulo, SP, Brazil
Background
The pathogenesis remains poorly understood. The deposition of schistosomial antigens in the glomeruli, associated with the formation of immune complexes, has been considered one of the main mechanisms involved in renal injury
Methods
A single-center study was conducted including patients who underwent renal biopsy between 2002 and 2024. Histopathological data were analyzed, along with the presence of schistosomotic antigen by immunohistochemistry.
Results
Twelve patients were included, median age of 41.5 (37-56) years old, with a predominance of males (75%) and patients from the Northeast region of Brazil (83.3%). Mixed syndrome was the most frequent clinical presentation, associated with high proteinuria and renal dysfunction (Table 1). The predominant histological pattern was membranoproliferative glomerulonephritis (66%). Schistosomal antigen was identified in 83.3% of the samples, particularly in cases of membranoproliferative glomerulonephritis, figure 1.
Conclusion
These findings reinforce the role of antigen deposition and persistent immune response in the immunopathogenesis of the disease, highlighting the need for larger studies.
Laboratory findings of the patients (n = 12)
| Variable | Results |
| Serum creatinine (mg/dL) | 1.8 (1.26–2.68) |
| GFR (mL/min/1.73 m2) | 39 (24–59) |
| Proteinuria (g/24 h) | 8.2 (3.6–10.2) |
| Serum albumin (g/dL) | 2.2 (1.5–2.6) |
| Low C3 (%) | 58.3 |
| Low C4 (%) | 41.7 |
| Cryoglobulinemia, n(%) | 3 (25%) |
median (interquartile range)
Figure 1, Immunohistochemistry of renal tissue from a patient with schistosomiasis-associated glomerulopathy. Hematoxylin-eosin staining, with brown staining in positive cases. (A) Negative control; B, C, and D: Positivity for the antibody against the schistosomiasis antigen.