Abstract: FR-PO1038
Self-Reported Physical Function Is Associated with Objective Functional Capacity and Physical Performance in Patients on Hemodialysis
Session Information
- Hemodialysis: Clinical Challenges, Patient-Centered Outcomes, and Quality of Life
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Sun, Chien Yao, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Campos, Monique Opuszcka, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Giourdas, Ashley Danielle, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Narayanan, Gayatri, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Groninger, Nolan, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Dillman, Drake, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Stafford, Lauren H., Indiana University School of Medicine, Indianapolis, Indiana, United States
- Alarcon Acurero, Leonardo Jose, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Burney, Heather, Indiana University School of Medicine, Indianapolis, Indiana, United States
- Lim, Kenneth, Indiana University School of Medicine, Indianapolis, Indiana, United States
Background
Impaired functional capacity and reduced physical function are major complications in patients on hemodialysis (HD) and tightly linked to numerous adverse outcomes including falls, hospitalizations, and mortality. Despite this, objective assessment of functional capacity (by gold-standard cardiopulmonary exercise testing, CPET) or even basic physical performance tests are rarely conducted as part of routine care of HD patients. PROMIS Physical Function (PF) offers a low-burden patient-reported measure of endurance and lower-extremity mobility, but whether it can be used to track objective functional capacity or basic physical function measures in HD patients is unclear.
Methods
We performed a cross-sectional analysis of n=60 patients in the ongoing ROCK-D (Redefining Cardiovascular Risk Assessment in Dialysis Patients) cohort. All patients underwent CPET, 6-minute walk distance (6MWD), gait speed, and Short Physical Performance Battery (SPPB). Patients were stratified by PROMIS PF T-score as low-PF (<40, n=14) vs high-PF (≥40, n=46). Group comparisons used t-test, Mann-Whitney U, or Fisher's exact tests. Multivariable linear regression adjusted for age, sex, and albumin estimated independent associations.
Results
Low-PF compared to high-PF group had similar age (53.4 vs 50.6 years, P=0.82), male sex (57.1% vs 63.0%, P=0.76), body mass index (26.4 vs 29.0 kg/m2, P=0.14), and hemoglobin (10.3 vs 11.0 g/dL, P=0.17), but lower albumin (3.9 vs 4.2 g/dL, P=0.010). VO2Peak was similar between groups (10.8 vs 12.6 mL/min/kg, P=0.056). Low-PF had lower oxygen uptake efficiency slope, OUES (1.0 vs 1.4, P<0.001), shorter endurance time (6.7 vs 8.3 min, P=0.009), and higher heart rate reserve (44.2% vs 34.0%, P<0.001). Additionally, low-PF had lower 6MWD (322.9 vs 409.5 m, P=0.007) and gait speed (1.1 vs 1.2 m/s, P=0.026). SPPB, grip strength, and chair stands in 30 sec were similar (P>0.05). After adjustment, low-PF remained associated with lower OUES (β=−0.27, P=0.006), shorter endurance time (β=−2.18 min, P=0.031), higher heart rate reserve (β=+7.92%, P=0.049), lower 6MWD (β=−76.4 m, P=0.015), and gait speed (β=−0.12 m/s, P=0.043).
Conclusion
Patients with low PROMIS PF (<40) had impaired functional capacity and reduced physical performance in HD, supporting its use as a scalable screening tool for assessing physical function impairment in patients on HD.
Funding
- Other NIH Support