Abstract: FR-PO0973
Effects of Nonsteroidal Anti-Inflammatory Drugs on Blood Pressure in Postpartum Women
Session Information
- Women's Health and Kidney Diseases
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Women's Health and Kidney Diseases
- 2100 Women's Health and Kidney Diseases
Authors
- Maharaj, Sime, Weill Cornell Medicine, New York, New York, United States
- Malha, Line, Weill Cornell Medicine, New York, New York, United States
Background
Although non-steroidal anti-inflammatory drugs (NSAIDS) are commonly used to manage postpartum pain, their effects on delayed postpartum blood pressure (BP) levels are controversial, especially in populations that are at a high risk for postpartum morbidity from hypertension. We aim to evaluate if postpartum NSAID use is associated with an increase in systolic or diastolic BP in the weeks following delivery in women at high risk for preeclampsia and hence more vulnerable to hypertensive complications postpartum.
Methods
We conducted a retrospective nested cohort study including pregnant women at high risk for preeclampsia (with a history of diabetes, kidney disease, autoimmune disease, hypertension, prior preeclampsia or multifetal gestation) across two academic centers in New York. The primary outcome assessed was the change in maximum BP (systolic: SBP and diastolic: DBP) recorded in the postpartum period before hospital discharge compared to the postpartum appointment. Secondary outcomes include rate of representation, incidence of severe hypertension (HTN), defined as SBP ≥ 160 or DBP ≥ 110, in the period between discharge and the postpartum visit and change in number of antihypertensives from discharge to the postpartum visit.
Results
A total of 365 high risk women were evaluated with a postpartum visit mean of 6.2 weeks post-delivery. In the NSAID group (n = 242), systolic BP decreased by an average of 21.8 mmHg, compared to 24.1 mmHg in the no-NSAID group (n = 66, p = 0.44). Diastolic BP decreased an average of 10.8 mmHg in the NSAID group, compared to 13.1 mmHg in the no-NSAID group (p = 0.35). The incidence of representation was similar in both groups: 2.9% in the NSAID group compared to 2.4% in the non-NSAID group (p = 1.00). Rates of recorded severe HTN were also similar: 2.5% in the NSAID group compared to 2.4% in the non-NSAID group (p = 1.00). Changes in number of antihypertensives prescribed from discharge to the postpartum visit was found to be not significant (p = 0.07).
Conclusion
In women at high risk for preeclampsia, NSAIDs did not significantly affect BP changes between delivery and the postpartum visit. Randomized trials dedicated to the study of BP in the first 6 weeks postpartum and the impact of NSAIDs in women at high risk for postpartum hypertension are need.