Kidney Week

Abstract: PUB074

Body Fat Accumulation Is Associated with Systemic Inflammation and Peritonitis in Patients Undergoing Peritoneal Dialysis

Session Information

• Publication Only

Category: Dialysis

• 802 Dialysis: Home Dialysis and Peritoneal Dialysis

Authors

• Fujii, Ai, Kanazawa Medical University, Kanazawa, Japan

Ai Fujii, MD, PhD

• Hayashi, Mizuki, Kanazawa Medical University, Kanazawa, Japan

Mizuki Hayashi

• Takei, Hajime, Kanazawa Medical University, Kanazawa, Japan

Hajime Takei, MSc

• Kondo, Takaya, Kanazawa Medical University, Kanazawa, Japan

Takaya Kondo, MD

• Katsura, Yasutaka, Kanazawa Medical University, Kanazawa, Japan

Yasutaka Katsura, MD

• Nagayama, Serina, Kanazawa Medical University, Kanazawa, Japan

Serina Nagayama

• Sakuma, Megumi, Kanazawa Medical University, Kanazawa, Japan

Megumi Sakuma

• Matsuda, Yuto, Kanazawa Medical University, Kanazawa, Japan

Yuto Matsuda, MD

• Shirakawa, Tomohiko, Kanazawa Medical University, Kanazawa, Japan

Tomohiko Shirakawa, MD

• Kumano, Sho, Kanazawa Medical University, Kanazawa, Japan

Sho Kumano, MD

• Okino, Kazuaki, Kanazawa Medical University, Kanazawa, Japan

Kazuaki Okino, MD, PhD

• Fujimoto, Keiji, Kanazawa Medical University, Kanazawa, Japan

Keiji Fujimoto, MD, PhD

• Yokoyama, Hitoshi, Kanazawa Medical University, Kanazawa, Japan

Hitoshi Yokoyama, MD, PhD

• Furuichi, Kengo, Kanazawa Medical University, Kanazawa, Japan

Kengo Furuichi, MD, PhD

Background

Patients undergoing peritoneal dialysis (PD) are chronically exposed to glucose-based dialysate and may develop body fat accumulation. Although adiposity has been associated with systemic inflammation and infection risk, its role in PD-related peritonitis remains unclear. This study examined the association of body fat accumulation with inflammation and subsequent peritonitis in patients receiving PD.

Methods

We conducted a single-center observational study of 23 patients undergoing PD. Total, visceral, and subcutaneous fat volumes were measured by computed tomography at baseline. Serum C-reactive protein (CRP), albumin, and clinical outcomes were collected. Patients were divided according to the development of peritonitis during follow-up.

Results

Baseline CRP levels were positively correlated with total, visceral, and subcutaneous fat volumes: total fat, p=0.03; visceral fat, p=0.05; and subcutaneous fat, p=0.02. During follow-up, peritonitis occurred in 13 of 23 patients. Patients who developed peritonitis had significantly higher visceral fat volume, p=0.03, and subcutaneous fat volume, p=0.01, than those without peritonitis. Total fat volume was numerically higher in the peritonitis group but did not reach statistical significance, p=0.30. Patients with visceral fat accumulation ≥100 cm² tended to develop peritonitis earlier than those with lower visceral fat volume, p=0.07. Baseline serum albumin levels were similar between patients with and without peritonitis, p=0.99.

Conclusion

Body fat accumulation was associated with systemic inflammation and subsequent peritonitis in patients undergoing PD. These findings suggest that excess adiposity, particularly visceral and subcutaneous fat accumulation, may be linked to peritonitis susceptibility, independent of baseline serum albumin levels.