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Abstract: FR-PO1121

Growth in Preemptive Deceased Donor Kidney Transplantation over the Last Decade

Session Information

Category: Transplantation

  • 2002 Transplantation: Clinical

Authors

  • Motter, Jennifer Danielle, NYU Langone Health, New York, New York, United States
  • Stewart, Darren E., NYU Langone Health, New York, New York, United States
  • Levan, Macey L., NYU Langone Health, New York, New York, United States
  • Potter, Steven, MedStar Georgetown University Hospital, Washington, District of Columbia, United States
  • Segev, Dorry L., NYU Langone Health, New York, New York, United States
  • Massie, Allan, NYU Langone Health, New York, New York, United States
  • Husain, Syed Ali, NYU Langone Health, New York, New York, United States
Background

Preemptive (prior to dialysis) deceased donor kidney transplantation (DDKT) is associated with improved graft and patient survival. Given changes to the kidney allocation system and donor pool, we sought to characterize trends in preemptive DDKT over the past decade.

Methods

Using Organ Procurement Transplantation Network data, we identified all adult (≥18 years) DDKT recipients from 2015-2025, excluding multi-organ transplants. We calculated the annual proportion of preemptive DDKTs, and used descriptive statistics to compare donor, recipient, and transplant characteristics over time.

Results

Preemptive DDKT rose from 6% (n=618) in 2015 to 14% (n=2600) in 2025 (Figure 1). Compared to recipients in 2015-2017, those in 2024-2025 were older (median: 62 vs 57 years), more likely to be Black (30% vs 17%), have diabetes as cause of kidney failure (25% vs. 17%), have public insurance (55% vs 46%), and have attained >high school education (67% vs 63%) (p<0.01 for all) (Figure 2). Recipients in 2024-2025 had shorter median waiting time (273 vs 418 days) and received organs from donors who were older (median: 46 vs 35 years), more likely to have diabetes (13% vs 6%) or hypertension (41% vs 24%), more likely to have donated after circulatory death (47% vs 22%), and had a higher KDRI (median: 1.4 vs. 1.1) (p<0.001 for all).

Conclusion

Preemptive DDKT has grown rapidly over the past decade, with expansion among historically underrepresented groups and use of medically complex donors, reflecting the rise in use of suboptimal organs to avoid dialysis.

Figure 1