Abstract: SA-PO0639
Characterization of Nutritional Intake by Disease Activity Status in IgAN
Session Information
- Glomerular Diseases: Clinical, Outcomes, and Therapeutics Research - Other
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Saha, Manish K., The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
- Falk, Ronald, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
- Carroll, Ian, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
- Patel, Kush J., Rutgers The State University of New Jersey, New Brunswick, New Jersey, United States
- Lester, Judy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
- Zamora, Daisy Daisy Zamora, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Background
Current evidence suggests mechanistic links between the immune network in the gut-associated lymphoid tissue and IgA nephropathy (IgAN). Dietary factors by a multitude of mechanisms shape the immune profile in the gut. Current knowledge gaps exist on the role of dietary factors that modulate the immune system in the gut. We evaluated the dietary intake of food constituents to compare the consumption of macro- and micro-nutrients among patients with IgAN, active and remission, and healthy controls (HC).
Methods
We conducted a cross-sectional study using a previously validated interviewer-administered 24-hour Dietary Assessment software Tool. This captures detailed information on intake of food/beverage, portion sizes, preparation methods, and supplement use. Participants were asked to maintain their usual diet during this period. We enrolled subjects with active IgAN disease (N=14), remission (N=19), and sex-, race-, and BMI-matched healthy controls (N=23). Disease status was classified based on CureGN criteria. Statistical Analysis: Group differences in nutrient intake were measured using t-tests
Results
Subjects with active IgAN had significantly lower intake of dietary fiber (p=0.03) and a trend towards lower intake of vitamin A containing food items (p=0.13) compared to HC. IgAN in remission had a trend towards lower intake of fiber and vitamin A containing food items compared to HC (see Table 1). There were no differences in total intake of daily calories, carbohydrates, protein, or fat content among subjects with IgAN, remission and active, compared to HC
Conclusion
Observed differences in dietary intake of nutrients could contribute to disease activity status in IgAN. Future multi-omics and in-vitro studies are required to elucidate the mechanistic pathways that link diet-derived metabolites and gut immune system.
Acknowledgment
NephCure and CureGN