Kidney Week

Abstract: PUB075

Serum Cancer Antigen (CA-125) Levels and Their Correlation with Bioimpedance Parameters in Patients on Automated Peritoneal Dialysis

Session Information

• Publication Only

Category: Dialysis

• 802 Dialysis: Home Dialysis and Peritoneal Dialysis

Authors

• Zuñiga, Erik Manuel, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Erik Manuel Zuñiga, MD

• Madero, Magdalena, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Magdalena Madero, MD

• Leal, Gabriela, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Gabriela Leal

• Guillermo Durán, Juan Pablo, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Juan Pablo Guillermo Durán, MD

• Lopez, Diana Laura, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Diana Laura Lopez, MD

• Garcia, Abel Lucio, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Abel Lucio Garcia, MEd

• Cano Escobar, Karla Berenice, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Karla Berenice Cano Escobar, MD

Background

Volume overload is a major cause of morbidity and mortality in patients with chronic kidney disease (CKD) treated with peritoneal dialysis (PD). Early detection is challenging because of the limitations of physical examination and conventional biomarkers. Carbohydrate antigen 125 (CA-125) has been proposed as a biomarker of systemic congestion. However, in PD patients, chronic exposure to dialysate may alter its levels.
Objective: To describe serum CA-125 levels and evaluate their correlation with bioimpedance parameters in patients with CKD undergoing automated peritoneal dialysis.

Methods

This cross-sectional observational study included 48 adult patients on automated peritoneal dialysis. Demographic, clinical, biochemical, and bioimpedance parameters were analyzed. Associations between CA-125 and the extracellular water/total body water ratio (ECW/TBW), phase angle, and the difference between total body weight and dry weight were assessed using Spearman correlation. An ECW/TBW cutoff >0.385 was used.

Results

Median age was 37.5 years, and 62.5% were women. Median CA-125 was 12.15 U/mL (IQR 8.5–19.3). Median ECW/TBW was 0.397 (IQR 0.382–0.400); 28 patients (58.3%) had values >0.385. The difference between total body weight and dry weight was 1.3 kg (IQR 0.4–2.7). There was no correlation between CA-125 and ECW/TBW (rho = -0.035; p = 0.813). A positive trend was observed between CA-125 and the difference between total body weight and dry weight (rho = 0.262; p = 0.079), and an inverse trend with phase angle (rho = -0.282; p = 0.057). When phase angle was dichotomized at 4.64°, no significant differences in CA-125 levels were observed (p = 0.135).

Conclusion

Serum CA-125 levels were not correlated with the bioimpedance-derived overhydration index. The observed median CA-125 suggests that levels were not significantly modified by chronic exposure to dialysate. Trends toward association with the difference between total body weight and dry weight and with phase angle suggest a possible link with extracellular volume expansion and nutritional/inflammatory status. Further studies are needed to confirm these findings.