Abstract: SA-PO1265
Clinical Characteristics of Renal Cell Carcinoma in Patients on Dialysis: Associations with Dialysis Vintage, Acquired Cystic Kidney Disease, and Bilateral Tumors
Session Information
- Onconephrology: Epidemiological Trends, Risk Stratification, and Clinical Outcomes
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Onconephrology
- 1600 Onconephrology
Authors
- Sakai, Suzuna, Nagasaki Kidney Center, Nagasaki, Japan
- Funakoshi, Satoshi, Nagasaki Kidney Center, Nagasaki, Japan
- Imamura, Ryoichi, Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
- Ohno, Sakurako, Nagasaki Kidney Center, Nagasaki, Japan
- Hashiguchi, Jyunichiro, Nagasaki Kidney Center, Nagasaki, Japan
Background
Renal cell carcinoma (RCC) is more common in patients with end-stage kidney disease, and long-term dialysis with acquired cystic kidney disease (ACKD) may contribute to its development. However, the clinical characteristics of RCC in maintenance dialysis patients remain insufficiently described in single-center cohorts.
Methods
We retrospectively analyzed 33 dialysis patients diagnosed with RCC at our center. We examined age at diagnosis, sex, dialysis vintage, presence of ACKD, laterality, histologic subtype, T stage, treatment, and mortality. We also explored the association between ACKD and bilateral tumors and assessed the relationship of surgery and T stage with time from diagnosis to death among deceased patients.
Results
Of 33 patients, 29 were men and 4 were women. Median age at RCC diagnosis was 66 years, and median dialysis vintage was 11 years. ACKD was present in 9 patients. Clear cell RCC was the most common histologic subtype (n=12), followed by acquired cystic disease-associated RCC (n=7). T1 disease accounted for 26 cases. Patients with ACKD had significantly longer dialysis vintage than those without ACKD (15 vs. 8.5 years, p=0.015). Bilateral tumors were more frequent in patients with ACKD than in those without ACKD (44.4% vs. 13.6%, p=0.15), although this did not reach statistical significance. Twenty-two patients died during follow-up. Deceased patients were diagnosed earlier than survivors, suggesting an effect of longer observation time. Among deceased patients, time from diagnosis to death tended to be longer in those who underwent surgery than in those who did not (1098 vs. 662 days, p=0.23). No clear association was observed between T stage and time to death.
Conclusion
RCC in dialysis patients occurred predominantly in men and after relatively long dialysis duration. ACKD-positive patients had longer dialysis vintage and tended to have more bilateral tumors, suggesting that long-term dialysis-related renal changes may contribute to RCC development in this population.
Funding
- Private Foundation Support