Abstract: SA-PO1015
Chronodisruption and Chronotype Distribution Among Patients on Hemodialysis: Effect on Sleep Quality, Hemodialysis Adequacy, and Quality of Life
Session Information
- Hemodialysis: Risk Factors, Epidemiology, and Outcomes
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Sayed, Ahmed Yamany, Cairo University Kasr Alainy Faculty of Medicine, Cairo, Cairo Governorate, Egypt
- Abdalla, Abdelrahman Magdy mohamed, Armed Forces College of Medicine, Cairo, Cairo Governorate, Egypt
- Abuzied, Mohamed Ali Ezzat, Ain Shams University Faculty of Medicine, Cairo, Cairo Governorate, Egypt
Background
Chronodisruption, defined as misalignment between endogenous circadian rhythms and external schedules, is common in hemodialysis patients and may contribute to poor sleep quality, blood pressure instability and adverse clinical outcomes.
Our study aims to evaluate chronotype distribution in hemodialysis patients and assess the effect of chronotype-based dialysis scheduling on sleep quality, Hemodialysis adequacy, blood pressure variability, metabolic parameters and clinical outcomes.
Methods
This prospective, cross-sectional analytical study was conducted over 9 months in hemodialysis units of tertiary care military hospitals in Egypt. A total of 120 adult patients on maintenance hemodialysis (6–12 months) were enrolled after ethical approval and informed consent. Chronotype was assessed using the Morningness–Eveningness Questionnaire (MEQ). Sleep quality, daytime sleepiness, quality of life, and adherence were evaluated using PSQI, ESS, WHOQOL-BREF and ESRD-AQ respectively. Patients were classified into morning and evening chronotypes and followed for 3 months. Chronotype-based modification of dialysis timing was implemented where feasible. Outcomes included sleep duration, quality of life, intradialytic blood pressure variability, laboratory parameters, dialysis adequacy and missed sessions.
Results
Chronotypes were nearly equally distributed (52.5% morning, 47.5% evening). Evening chronotype was associated with male gender and night-shift work (p < 0.05). After chronotype modification, significant improvements were observed in blood pressure stability (85.8%, p < 0.001), phosphorus (5.34 ± 1.63 to 4.60 ± 0.74 mg/dL, p < 0.001), potassium (5.07 ± 0.96 to 4.46 ± 0.48 mmol/L, p < 0.001), and urea reduction ratio (57.8 ± 9.2% to 63.8 ± 5.3%, p < 0.001). Sleep duration increased (7.0 ± 1.5 to 9.2 ± 0.5 hours, p < 0.001), quality of life improved, and number of missed sessions decreased (p < 0.001). No significant differences were observed in echocardiographic findings or major clinical outcomes.
Conclusion
Chronotype-based dialysis scheduling significantly improves sleep quality, adherence to treatment, quality of life , blood pressure stability, metabolic control in hemodialysis patients. Aligning dialysis timing with circadian rhythms represents a simple, cost-effective strategy to reduce chronodisruption and optimize patient outcomes.