Abstract: SA-PO0294
Insights on AKI Risk Predictors, Incidence, and Complications in Neurocritical Patients
Session Information
- AKI: Epidemiology and Risk Factors
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Abdelgawad, Mostafa Abdelnasier, Ain Shams University Faculty of Medicine, Cairo, Cairo Governorate, Egypt
- Temraz, Kareem Abdel-aziz, Armed Forces College of Medicine, Cairo, Cairo Governorate, Egypt
- Abuzied, Mohamed Ali Ezzat, Ain Shams University Faculty of Medicine, Cairo, Cairo Governorate, Egypt
Background
Acute kidney injury (AKI) is a frequent and serious complication among critical patients, associated with increased morbidity, mortality, and prolonged hospital stay. In neurocritical care, AKI poses a unique challenge because of the complex interaction between neurological injury and systemic organ dysfunction. Previous studies have reported AKI incidence rates ranging from 15 to 40% in patients with acute brain injury; however, prospective data, particularly from low- and middle-income countries remain limited
Our study aims to address the predictors of AKI among neurocritical patients and its impact on the patients' clinical outcomes including ICU stay, the need for hemodialysis and mortality rate
Methods
This 9-month prospective cohort study was conducted in the intensive care units of tertiary military hospitals in Egypt. A total of 130 patients with acute brain injury admitted to neurocritical care units were enrolled following ethical approval and informed consent. Patients were stratified according to KDIGO criteria into AKI and non-AKI groups based on the development of AKI during ICU stay. Demographic characteristics, comorbidities, exposure to nephrotoxic agents, renal function parameters, inflammatory biomarkers, etiology of brain injury, length of ICU stay, the need for hemodialysis, mechanical ventilation and inotropes were assessed
Results
Among 130 neurocritical care patients, AKI developed in 27.7%, with a nearly equal distribution across KDIGO stages I–III. Cerebrovascular stroke was the most common cause of ICU admission (36.1%), while hypertension and diabetes mellitus were the predominant comorbidities. Patients with AKI had significantly lower GCS scores, higher rates of sepsis/septic shock, greater exposure to nephrotoxins and contrast agents, prolonged ICU stay and markedly increased 28-day mortality compared with non-AKI patients (p<0.001 for each). AKI was also associated with poorer clinical outcomes, including need for hemodialysis, mechanical ventilation and inotropic support
Conclusion
In neurocritical ill patients with acute brain injury, AKI is a common multifactorial complication associated with systemic inflammation, hemodynamic instability and underlying comorbidities. AKI significantly predicts prolonged ICU stay and increased mortality highlighting the importance of early renal monitoring and targeted preventive strategies to improve outcomes