Kidney Week

Abstract: SA-PO0844

Clinicopathologic Phenotypes Across Native Kidney Biopsy Diagnoses: A Mexican Cohort Study

Session Information

• Glomerular Diseases: Management, Evolving Strategies, and Practice-Changing Advances
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Glomerular Diseases

• 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics

Authors

• Fonseca Chávez, Alfredo, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Alfredo Fonseca Chávez, MD

• Soto, Virgilia, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Virgilia Soto, MD

• Roldan, Ruben Garrido, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Ruben Garrido Roldan, MD

• Campos Núñez, Guadalupe, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City, Mexico

Guadalupe Campos Núñez, MD

Background

Kidney biopsy remains a cornerstone of kidney disease evaluation. Multidomain characterization of biopsy-based cohorts remains limited. We aimed to describe the clinical, laboratory, and histopathologic characteristics of a kidney biopsy cohort and to characterize integrated phenotypes using a clinicopathologic heatmap approach.

Methods

Retrospective cohort including kidney biopsies performed at a tertiary center between 2020 and 2024. Only index native kidney biopsies obtained at initial diagnosis were included. Clinical, laboratory, and histopathologic variables were collected. Biopsies were classified into diagnostic groups. Clinicopathologic variables were dichotomized and represented as group-level frequencies in an integrated clinicopathologic heatmap.

Results

249 biopsies were included. Median age 42 years, 49.4% male, and median eGFR was 31 mL/min/1.73m2 (Table 1). Global glomerulosclerosis >25% was observed in 41.8% of biopsies, and interstitial fibrosis >25% in 57.4% of cases (Table 2). Podocytopathies were the most frequent group, followed by diabetic nephropathy (Figure 1). Multidomain clinicopathologic patterns emerged across diagnostic groups. Diabetic nephropathy demonstrated greater chronicity and a lower eGFR, while lupus nephritis showed lower complement levels, higher endocapillary hypercellularity, and extracapillary proliferation (Figure 2).

Conclusion

This multidomain approach may facilitate phenotypic mapping and improve the interpretation of injury patterns across kidney diseases.