Abstract: PUB239
Prevalence of Septrin-Resistant Urinary Tract Infection in Kidney Transplant Recipients: A Retrospective Single-Center Experience
Session Information
Category: Transplantation
- 2002 Transplantation: Clinical
Authors
- Ibrahem, Mahmoud Suliman Mohammed Salih, Hamad General Hospital, Doha, Qatar
- Elamin, Nusiba Hafiz, Hamad General Hospital, Doha, Qatar
- Nauman, Awais, Hamad General Hospital, Doha, Qatar
- Abuhelaiqa, Essa, Hamad General Hospital, Doha, Qatar
Background
Urinary tract infection (UTI) is the most common infection among kidney transplant recipients (KTRs). UTIs in KTRs may lead to acute pyelonephritis and urosepsis, graft dysfunction, graft loss, recurrent UTIs, antibiotic-resistant infections, urinary tract structural complications, acute allograft rejection, and increased morbidity and mortality. Septrin is recommended by international guidelines as prophylaxis for both UTI and PJP. We sought to assess the prevalence of septrin resistance in UTI isolates in our center.
Methods
It was a retrospective single-center cohort study. The objective was to evaluate the prevalence of septrin-resistant UTI in KTRs within one year following transplantation. We reviewed the records of patients who underwent Kidney transplantation in the period from January 2023 to December 2024 in Qatar.
Results
We studied 112 patients, of whom 64 (57.1%) developed a UTI during the first year. Among these, 44 (68.7%) had isolates resistant to Septrin. Klebsiella pneumoniae was the most common organism, identified in 25 patients (39%), of whom 60% were Septrin-resistant. Escherichia coli was found in 31.2% of isolates, of which 12 (60%) were resistant to Septrin. Enterococcus faecalis was identified in 10 patients (15.6%). Pseudomonas aeruginosa was found in 3 patients (4%), all of whom were resistant to septrin.
Conclusion
Approximately two-thirds of UTI-causing isolates in KTRs were resistant to septrin. Evaluation of antimicrobial susceptibility patterns, particularly resistance to Septrin, may support the need for alternative or additional prophylactic strategies. The use of ciprofloxacin, Nitrofurantoin, or cephalexin as adjunctive prophylaxis should be considered, as previous studies have reported high rates of Septrin resistance and demonstrated desirable outcomes.
Acknowledgment
I would like to thank my mentor and the team for their dedication and continuous support.
Figure 1 illustrates the percentage distribution of UTI isolates and their proportion of resistance to Septrin.