Abstract: FR-PO1039
Beyond Conventional Hemodialysis: Early Clinical and Patient-Reported Outcome Benefits of Online Hemodiafiltration in Qatar
Session Information
- Hemodialysis: Clinical Challenges, Patient-Centered Outcomes, and Quality of Life
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Fouda, Tarek Ahmed, Hamad Medical Corporation, Doha, Qatar
- Hamad, Abdullah Ibrahim, Hamad Medical Corporation, Doha, Qatar
- Aly, Sahar, Hamad Medical Corporation, Doha, Qatar
- Farooqi, Farrukh Ali, Hamad Medical Corporation, Doha, Qatar
- Yasin, Fadumo Yusuf, Hamad Medical Corporation, Doha, Qatar
- Singh, Poonam Ravinder, Hamad Medical Corporation, Doha, Qatar
- Ibrahim, Rania Abdelaziz, Hamad Medical Corporation, Doha, Qatar
- Alkadi, Mohamad M., Hamad Medical Corporation, Doha, Qatar
- Al-Malki, Hassan A., Hamad Medical Corporation, Doha, Qatar
- Ibrahim, Ashraf Ahmed Fawzy, Hamad Medical Corporation, Doha, Qatar
Background
Conventional hemodialysis (HD) effectively clears small solutes but inadequately removes middle-molecular-weight uremic toxins, contributing to persistent metabolic disturbances and symptom burden. Online hemodiafiltration (OL-HDF) combines diffusive and convective clearance, with superior middle-molecule clearance compared with conventional HD. In November 2024, our center introduced OL-HDF for the first time in Qatar. We evaluated its impact, compared with conventional HD, on dialysis adequacy, phosphorus clearance, and patient-reported outcome measures (PROMs).
Methods
We conducted a prospective, single-center, before-and-after study at the largest tertiary dialysis unit in Qatar serving approximately 475 maintenance HD patients. Thirty stable adult patients meeting eligibility criteria were enrolled. Baseline Kt/V, serum phosphorus, and symptom burden — assessed using the Integrated Palliative Care Outcome Scale (IPOS) via structured interviews — were collected on conventional HD. Patients were then transitioned to OL-HDF targeting high convective volumes according to unit protocol and reassessed after six months.
Results
Transition to OL-HDF resulted in significant improvements in dialysis adequacy, phosphorus control, and symptom burden. Mean Kt/V increased from 1.49 ± 0.18 to 1.78 ± 0.20 (p<0.01) and mean serum phosphorus decreased from 1.94 ± 0.45 to 1.07 ± 0.30 mmol/L (p<0.01). IPOS-measured symptom burden improved markedly, with a 37% reduction in moderate-to-severe symptoms (moderate: 52%→25%; severe: 10%→0%; p<0.05).
Conclusion
Transitioning patients from conventional HD to OL-HDF produced significant improvements in dialysis adequacy, phosphorus control, and patient-reported outcome (PROMs) within six months. OL-HDF implementation was feasible and associated with clinically meaningful improvements in dialysis adequacy, mineral and metabolic control, and patient-centered outcomes.