Abstract: FR-PO0530
Dietary Inflammatory Index and All-Cause Mortality in Adults with Cardiovascular-Kidney-Metabolic Syndrome
Session Information
- CKM: Clinical - Trials, Epidemiology, and Biomarkers
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Cardiovascular-Kidney-Metabolic Health
- 602 Cardiovascular-Kidney-Metabolic Health: Clinical
Authors
- Yan, Han, Shanghai Changzheng Hospital, Shanghai, China
- Xu, Jing, Shanghai Changzheng Hospital, Shanghai, China
- Xue, Cheng, Shanghai Changzheng Hospital, Shanghai, China
- Chunlai, Lu, 905th Hospital of PLA Navy, Shanghai, China
- Mao, Zhiguo, Shanghai Changzheng Hospital, Shanghai, China
Background
Chronic inflammation promoted disease progression and worsen patients' prognosis in cardiovascular-kidney-metabolic (CKM) syndrome. The dietary inflammatory index (DII), which quantifies the inflammatory potential of overall diet and has been associated with cardiovascular, metabolic, and kidney outcomes. However, the association between DII and mortality in adults with CKM syndrome remains unclear.
Methods
Adults aged ≥20 years with CKM syndrome were identified from the National Health and Nutrition Examination Survey 2011–2018. Participants with complete dietary recall and mortality follow-up data were included. DII was analyzed continuously and by tertiles. Survey-weighted Cox models assessed the association between DII and all-cause mortality. Weighted Kaplan-Meier curves compared survival across DII tertiles.
Results
Among 9455 adults with CKM syndrome, higher DII was associated with lower income, more smoking, and greater burdens of hypertension, diabetes, CKD. Each 1-unit increase in DII was associated with about 10% higher all-cause mortality (HR, 1.10; 95% CI, 1.04–1.17).The highest versus lowest DII group had increased mortality risk (HR, 1.40; 95% CI, 1.06–1.87), with a positive trend across tertiles (p for trend=0.0191). Weighted Kaplan-Meier curves showed lower survival at higher DII levels (weighted p=0.0105).
Conclusion
In a representative cohort of adults with CKM syndrome, higher dietary inflammatory potential was associated with increased all-cause mortality. These findings suggest that dietary inflammatory burden may be relevant to mortality risk stratification and intervention was erged to be lunched.
Acknowledgment
We thank the participants and staff of the National Health and Nutrition Examination Survey (NHANES). No specific funding was received for this work.