Abstract: TH-PO0749
Clinical Outcomes in Patients with Cancer and AKI Requiring Hemodialysis-Type Kidney Replacement Therapy at a Tertiary Referral Center, 2023-2025
Session Information
- AKI: Critical Care, CKRT, Cardiorenal Syndromes, and Clinical Outcomes
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 102 AKI: Clinical, Outcomes, and Trials
Authors
- Guerrero, Scarlyn Patricia, Hospital General de la Plaza de la Salud, Santo Domingo, Dominican Republic
- Rojas, Limber Ivan, Hospital General de la Plaza de la Salud, Santo Domingo, Dominican Republic
Background
Acute kidney injury requiring kidney replacement therapy in hospitalized oncologic patients is associated with high morbidity and mortality. Data regarding outcomes in critically ill cancer patients requiring dialysis in Latin America remain limited.
Methods
We conducted a retrospective observational study of hospitalized oncologic patients with AKI requiring KRT at Hospital General Plaza de la Salud in the Dominican Republic between 2023–2025. Demographic, clinical, and critical care variables were analyzed, including KRT modality, APACHE II score, vasopressor support, invasive mechanical ventilation, ICU stay, and mortality. Associations with mortality were evaluated using chi-square analysis, odds ratios (OR), and logistic regression.
Results
A total of 42 patients were included. The mean age was 61.4 ± 13.8 years, and overall mortality was 66.7%. Continuous or combined KRT modalities were associated with higher mortality than conventional intermittent hemodialysis (p=0.012). Vasopressor requirement was strongly associated with mortality (OR 17.3; 95% CI 1.98–151.4; p=0.002). Higher APACHE II scores were associated with worse outcomes and prolonged ICU stay. In multivariable logistic regression, vasopressor use remained the variable with the strongest association with mortality.
Conclusion
Hospitalized oncologic patients requiring KRT for AKI had very high mortality. Greater illness severity, vasopressor support, and prolonged or combined dialysis modalities were associated with worse clinical outcomes.