Abstract: PUB067
Effect of Urea Reduction on Outcomes in Hospitalized Patients Undergoing Acute Hemodialysis
Session Information
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Author
- Fragoso, Paola Montserrat, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, Mexico
Background
Introduction: Acute hemodialysis is a fundamental intervention in patients with acute kidney injury and decompensated chronic kidney disease. However, clinical outcomes depend on both the underlying etiology and dialysis adequacy. Identifying factors associated with mortality in this context may help guide strategies to improve patient care.
Methods
This was an observational, descriptive, retrospective study including 61 patients who underwent acute hemodialysis at a tertiary-care hospital. Demographic, clinical, biochemical, and dialysis adequacy variables (urea reduction percentage, URR) were analyzed. Outcomes were compared between survivors and non-survivors using statistical tests (t-test and Fisher’s exact test).
Results
The mean age was 54 years; 55.7% were male and 70.5% had acute kidney disease. The main etiologies were diabetes (31.1%), hypertension (23.0%), and sepsis (14.8%). In-hospital mortality was 18.0% (11 patients).
Comparing survivors versus non-survivors:
Mortality was more frequent in males (81.8% vs 60%) and in patients with acute presentation (54.5% vs 24%).
Sepsis was the leading cause among non-survivors (54.5%), whereas diabetes and hypertension predominated among survivors.
No significant differences were observed in age, hemoglobin, urea, creatinine, potassium, or sodium levels.
URR was significantly lower in non-survivors (25.6% vs 43.9%, p = 0.038).
Conclusion
In this cohort, sepsis and inadequate dialysis (low %URR) were associated with higher mortality in patients undergoing acute hemodialysis. These findings highlight the need to optimize dialysis dosing and strengthen comprehensive sepsis management in patients with renal failure.
Acknowledgment
Fragoso Carranza Paola Montserrat, Domínguez Franco Miguel Ángel, Pérez-Navarro Lucía, Department of Nephrology Hospital General de México “Dr Eduardo Liceaga”