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Kidney Week

Abstract: TH-PO0739

Postdischarge Outcomes After Recovery from Dialysis-Requiring AKI: A Retrospective Cohort Study from Qatar

Session Information

Category: Acute Kidney Injury

  • 102 AKI: Clinical, Outcomes, and Trials

Authors

  • Elshirbeny, Mostafa, Hamad Medical Corporation, Doha, Qatar
  • Ismail, Hany Ezzat Abdelaziz, Hamad Medical Corporation, Doha, Qatar
  • Abdul Rahman, Rasha, Hamad Medical Corporation, Doha, Qatar
  • Ali, Mohamed Yousif Mohamed Salih, Hamad Medical Corporation, Doha, Qatar
  • Abdelhalim, Mohamed, Hamad Medical Corporation, Doha, Qatar
  • Elsanoosi, Shaza Yousif, Hamad Medical Corporation, Doha, Qatar
  • Ibrahim, Ashraf Ahmed Fawzy, Hamad Medical Corporation, Doha, Qatar
  • Al-Malki, Hassan A., Hamad Medical Corporation, Doha, Qatar
  • Alkadi, Mohamad M., Hamad Medical Corporation, Doha, Qatar
Background

Acute kidney injury requiring dialysis (AKI-D) is associated with high morbidity and mortality, and many survivors subsequently progress to CKD, ESKD, or death after hospital discharge. We aimed to evaluate 90-day post discharge outcomes among patients recovering from AKI-D and identify predictors of ESKD and mortality.

Methods

This retrospective cohort study included adult patients admitted to our hospital between 2015 and 2025 who developed AKI-D and recovered with dialysis discontinuation before discharge. Patients with preexisting ESKD or dialysis dependence at discharge were excluded. The 90-day outcomes were classified as full recovery to within 25% of baseline kidney function, partial recovery, back to dialysis, or death. We used multinomial logistic regression to identify predictors of ESKD and mortality.

Results

A total of 392 patients were included with a mean age of 57.2±16.6 years; 63.0% were male and 44% had underlying CKD. Median serum creatinine increased from 92.5 µmol/L (IQR: 71-137) at baseline to 444 µmol/L (IQR: 306-666) at dialysis initiation, then improved to 150.5 µmol/L (IQR: 84-275) at discharge. The median number of dialysis sessions was 3 (IQR:2-6), while the median length of hospital stay was 25 days (IQR: 14-48). ICU admission was required in 65% of patients with a median ICU stay of 13 days (IQR: 6-26). The most common etiologies of AKI were multifactorial causes (41%), sepsis (24%), and other acute tubular injury (21%). Follow-up clinic attendance was 81.4% and was significantly lower among patients who progressed to ESKD or died (p=0.003). At 90 days post discharge, 63% of patients achieved full recovery, 25% had partial recovery, 7% were back to dialysis, and 5% died. Higher discharge creatinine independently predicted both dialysis (OR 1.012; p<0.001), and mortality (OR 1.006, p=0.001), while older age independently predicted mortality (OR 1.05, p=0.013).

Conclusion

Adverse long-term outcomes remain common following recovery from AKI-D. Higher discharge creatinine was a strong predictor of both renal progression and mortality. Our findings support the need for structured post-AKI-D outpatient follow-up and early nephrology involvement for high-risk patients.

Acknowledgment

To all members of the nephrology team at Hamad General Hospital