Kidney Week

Abstract: SA-PO0311

Post-Transplant Factors Associated with Kidney Replacement Therapy and Mortality After Liver Transplantation in Western Mexico

Session Information

• AKI: Epidemiology and Risk Factors
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Acute Kidney Injury

• 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

• Duran Lemus, America Isabel, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Jal., Mexico

America Isabel Duran Lemus, MD

• Chavez, Jonathan, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Jal., Mexico

Jonathan Chavez, MD, PhD

• Navarro Blackaller, Guillermo, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Jal., Mexico

Guillermo Navarro Blackaller, MD

• Medina, Ramon, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Jal., Mexico

Ramon Medina, MD

• Alcantar Vallin, Maria de la Luz, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Jal., Mexico

Maria de la Luz Alcantar Vallin, MD

Background

Acute kidney injury (AKI) following liver transplantation is associated with increased morbidity and mortality, although factors associated with progression to kidney replacement therapy (KRT) remain incompletely characterized. We aimed to evaluate post-transplant AKI severity and identify factors associated with postoperative KRT.

Methods

Pre- and post transplant clinical data were analyzed. AKI was defined per KDIGO criteria. The primary outcome was postoperative KRT requirement. Secondary outcomes included severe AKI, in-hospital mortality, and major postoperative complications.

Results

Among 28 patients (mean age 56.9 years; 64.3% male), post-transplant AKI occurred in 35.7% of patients; KDIGO C1 and C3 AKI occurred in 7.1% and 28.6%, respectively. Postoperative KRT was required in 25%, and 87.5% of KDIGO C3 patients progressed to KRT.
Patients requiring KRT demonstrated higher SOFA and APACHE II scores, increased transfusion requirements, and greater intraoperative bleeding. Major postoperative complications occurred in 53.6% of patients, most commonly infectious/septic. Patients requiring KRT had markedly higher in-hospital mortality (71.4% vs 0%, p=0.0002) and major postoperative complications (100% vs 38.1%, p=0.0069)

Conclusion

Postoperative KRT after liver transplantation is strongly associated with severe illness and a markedly increased risk of in-hospital mortality 71.4%.