Kidney Week

Abstract: SA-PO0822

Differences in Efficacy Between Two Ultrasound-Guided Percutaneous Kidney Biopsy Techniques at a Tertiary-Care Hospital in Mexico City

Session Information

• Glomerular Diseases: Management, Evolving Strategies, and Practice-Changing Advances
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Glomerular Diseases

• 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics

Authors

• Valenzo, Alan, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico

Alan Valenzo, MD

• Garcia-Flores, Octavio Rene, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico

Octavio Rene Garcia-Flores, MD

• Vasquez Jiménez, Enzo Christopher, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico

Enzo Christopher Vasquez Jiménez, MD

• Morales, Brenda, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico

Brenda Morales, MD

• Barrientos Feria, Sarai Ruth, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico

Sarai Ruth Barrientos Feria, MD

• Figueroa Gamiño, Diana Laura, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico

Diana Laura Figueroa Gamiño, MD, MEd

• Villanueva-Perez, Arisbeth, Operadora San Angel Inn SA de CV, Mexico City, CDMX, Mexico

Arisbeth Villanueva-Perez, MD

Background

Ultrasound-guided percutaneous renal biopsy allows for diagnosis, prognosis determination, and implementation of more precise treatments. While the standard approach is performed in the prone position using a longitudinal in-plane technique directed at the lower pole, the axial out-of-plane technique, directed towards Brödel's avascular zone, has been described as safe and effective.

Methods

A randomized, prospective, longitudinal, and analytical clinical trial was conducted from November 2025 to March 2026, in a tertiary center in Mexico City.

Results

36 participants underwent randomization at baseline, 26 met inclusion criteria: 16 in the conventional group and 10 in the axial group; 69.3% female, median age of 32.4 y, mean BMI of 26 kg/m2. The most prevalent comorbidity was hypertension 46.5%. Prior to biopsy, 46.1% of patients were on SGLT2 inhibitors. Baseline biochemical parameters showed a median serum creatinine of 2.07 mg/dL and a mean 24-hour proteinuria of 2.8 g. Nephrotic syndrome was the leading clinical indication for PRB (26.9%). A median of 2 passes (IQR 2.0–3.0) was performed per procedure across both techniques. The mean needle-to-kidney distance was greater in the conventional group (6.0 cm, IQR 5.62–7.1) compared to the out-of-plane group (4.69 cm, IQR 3.99–5.23; p=0.051). Regarding diagnostic yield, the overall median glomerular count was 21.5 (IQR 12.0–33.5). No significant difference in glomerular yield was observed between the longitudinal in-plane approach (22.5, IQR 13.0–33.0) and the axial out-of-plane approach (19.5, IQR 12.0–38.5; p=0.97). Lupus nephritis was the most frequent histopathological diagnosis (50%). 4 complications were recorded, with no significant difference in the safety profile between techniques (p=0.62).

Conclusion

Our findings demonstrate the axial out-of-plane percutaneous renal biopsy technique provides a diagnostic yield comparable to the conventional approach in a tertiary referral center. Both techniques exhibited a similar incidence of complications.

Funding

• Government Support – Non-U.S.