Abstract: SA-PO1108
Acute Peritoneal Dialysis and Hemodialysis Achieve Comparable Early Metabolic Improvement in Hospitalized Patients: A Mexican Real-World Cohort
Session Information
- Kidney Replacement Therapy and Care Delivery Innovations
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Dominguez Franco, Miguel Angel, Hospital Regional de Xalapa, Dr. Luis F. Nachon, Xalapa, Veracruz , Mexico
- Fragoso, Paola Montserrat, Hospital General de Mexico Dr Eduardo Liceaga, Mexico City, Mexico
- Mendez Morales, Mario Alejandro, Hospital General Dr. Belisario Dominguez, ISSSTE, Tuxtla Gutierrez, Mexico
- Espinosa Pulido, Nectar Alejandro, Hospital General Dr. Belisario Dominguez, ISSSTE, Tuxtla Gutierrez, Mexico
Background
Acute kidney replacement therapy (KRT) is essential in hospitalized patients with severe metabolic derangements. Although hemodialysis is commonly preferred for rapid solute clearance, acute peritoneal dialysis remains an important alternative in resource-limited settings, with limited comparative real-world data available in Latin American populations.
Methods
A retrospective multicenter cohort study included hospitalized adults receiving acute HD or PD. Baseline and follow-up biochemical variables, including BUN, creatinine, sodium, potassium, hemoglobin, URR, and hospital stay, were analyzed. Continuous variables were expressed as median [IQR], and categorical variables as frequencies and percentages. Within-group changes were analyzed using Wilcoxon signed-rank test, and between-group comparisons using Mann–Whitney U or Fisher’s exact test. Statistical significance was defined as p<0.05.
Results
A total of 54 hospitalized patients receiving acute KRT were included, including 26 treated with HD and 28 with PD. Both modalities achieved significant reductions in BUN, creatinine, and potassium levels (all p<0.001). HD demonstrated higher URR values and lower final creatinine and potassium concentrations, while final BUN levels were comparable between groups. No significant differences were observed in final sodium or hemoglobin levels. Biochemical trajectory analysis showed consistent metabolic improvement in both modalities during hospitalization (Figure 1).
Conclusion
In this multicenter real-world Mexican cohort, both acute HD and PD achieved significant early biochemical improvement in hospitalized patients requiring acute KRT. Although HD showed greater urea reduction and lower final creatinine and potassium levels, acute PD also achieved clinically meaningful metabolic control, supporting its use as a feasible therapeutic alternative in resource-limited settings.