Kidney Week

Abstract: SA-PO0876

Effects of Dietary Selenium on All-Cause Mortality According to Baseline Kidney Function

Session Information

• Health Maintenance, Nutrition, and Metabolism
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Health Maintenance, Nutrition, and Metabolism

• 1500 Health Maintenance, Nutrition, and Metabolism

Authors

• Hwang, Jungpihl, Keimyung University Daegu Dongsan Hospital, Daegu, Korea (the Republic of)

Jungpihl Hwang, DrMed

• Oh, Hyung Jung, Sheikh Khalifa Specialty Hospital, Ras Al-Khaimah, United Arab Emirates

Hyung Jung Oh, MD, PhD

• Kwon, Jin Kyung, Keimyung University Daegu Dongsan Hospital, Daegu, Korea (the Republic of)

Jin Kyung Kwon, MD

• Paek, Jin hyuk, Keimyung University Daegu Dongsan Hospital, Daegu, Korea (the Republic of)

Jin hyuk Paek, MD, PhD

• Jin, Kyubok, Keimyung University Daegu Dongsan Hospital, Daegu, Korea (the Republic of)

Kyubok Jin, MD, PhD

• Han, Seungyeup, Keimyung University Daegu Dongsan Hospital, Daegu, Korea (the Republic of)

Seungyeup Han, MD, PhD

• Lee, Jeonghwan, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Dongjak-gu, Seoul, Korea (the Republic of)

Jeonghwan Lee, MD, PhD

• Lee, Jung Pyo, Seoul National University Seoul Metropolitan Government Boramae Medical Center, Dongjak-gu, Seoul, Korea (the Republic of)

Jung Pyo Lee, MD, PhD

• Kim, Yaerim, Keimyung University Daegu Dongsan Hospital, Daegu, Korea (the Republic of)

Yaerim Kim, MD, PhD

Background

The antioxidant properties of selenium have diverse positive effects on human health, especially the thyroid and metabolic systems. The bioavailability of selenium from meals may be affected by kidney function due to the metabolic pathways involved. The purpose of this research was to examine the association between dietary selenium and several risk factors for death based on kidney function.

Methods

We used data from the US National Health and Nutrition Examination Survey 1999-2016. Based on a 1-day 24-hr dietary recall, the intake of selenium was divided by quintile; the third quintile was regarded as a reference. The subjects were divided into two groups based on the baseline estimated glomerular filtration rates ≥60 and <60 mL/min/1.73 m2. We used a multivariate Cox proportional hazard model to identify the impact of selenium on all-cause mortality.

Results

A total of 41,423 subjects were included in the study. There were 4,014 (9.7%) subjects with eGFR <60 mL/min/1.73 m2. The risk for all-cause mortality was significantly increased in subjects included in the 1^st quintile (adjusted hazard ratio [aHR] 1.12, 95% confidence interval [CI] 1.03-1.21) after adjustment with age, gender, ethnicity, education, income, comorbidities (hypertension, diabetes), BMI, total calorie intake, laboratory results (hemoglobin, serum albumin, total cholesterol, serum glucose, and estimated glomerular filtration rate). Lower intake of selenium increased mortality in subjects with eGFR ≥60 mL/min/1.73 m² (aHR 1.14, 95% CI 1.03-1.27 in 1^st quintile), but there was no association between selenium intake and all-cause mortality in subjects with eGFR <60 mL/min/1.73 m². However, lowest group for blood level of selenium showed increased risk of all-cause mortality irrespective of baseline kidney function.

Conclusion

Lower level of blood selenium significantly increased risk of all-cause mortality regardless of baseline kidney function. Deficiency in selenium intake significantly increased all-cause mortality, especially in subjects with preserved kidney function.