Abstract: TH-PO0865
First-in-Animal Evaluation of a Low-Water Portable Hemodialysis System Using OLI Sorbent in an Acute Ovine Urea Loading Model
Session Information
- Dialysis: Prescription, Physiology, and Treatment Optimization
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Weindl, Thomas C., Oli Technologies, Chicago, Illinois, United States
- Luo, Ray, Oli Technologies, Chicago, Illinois, United States
- Jacobson, Max E., Oli Technologies, Chicago, Illinois, United States
- DiLiberti, Serena, Oli Technologies, Chicago, Illinois, United States
- Carvajal, Michael A., Oli Technologies, Chicago, Illinois, United States
- Bogdanowicz, Les, Oli Technologies, Chicago, Illinois, United States
Background
Conventional hemodialysis requires high dialysate volumes and fixed infrastructure, limiting use in resource constrained settings and patients who would benefit from home based therapy. We evaluated the acute performance of a low water, portable hemodialysis prototype incorporating a novel sorbent (OLI Sorbent) in an anesthetized ovine urea loading model.
Methods
In non GLP acute studies, healthy sheep received intravenous urea to elevate BUN to approximately 100 mg/dL, after which extracorporeal circulation was established via arteriovenous access and maintained for several hours using the prototype system (OLI.Ver2; Revaclear 400 dialyzer, OLI Sorbent columns, low volume dialysate circuit). A zero calcium dialysate was used with supplemental systemic calcium infusion throughout. Serial blood samples were analyzed for BUN, electrolytes, ionized calcium, and hematocrit by point of care testing
Results
At baseline, BUN was approximately 100 mg/dL with stable serum electrolytes (sodium ~140, potassium ~4.4, chloride ~101 mmol/L). During dialysis, BUN was reduced by greater than 60%, while serum sodium, potassium, and chloride remained within narrow ranges throughout. Ionized calcium declined modestly, consistent with zero calcium dialysate composition. Hematocrit increased directionally with fluid removal, confirmed by pre and post session body weight, and no sorbent related adverse effects were observed.
Conclusion
In initial acute ovine studies, a low water portable hemodialysis system using OLI Sorbent achieved substantial BUN reduction with preservation of electrolyte balance and procedural tolerability. These findings support continued studies incorporating renal isolation and calcium containing dialysate to characterize solute kinetics, volume control, and biocompatibility in preparation for clinical translation.
Funding
- Commercial Support – Oli Technologies