Kidney Week

Abstract: TH-PO0707

Kidney Failure in Cancer-Related Mortality in the United States: A CDC WONDER Population-Based Analysis, 1999-2024

Session Information

• AKI: Prevention, Diagnostics, and Management
  October 22, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Acute Kidney Injury

• 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

• Vijayarao, Sree Sindhu, University of Miami Miller School of Medicine, Miami, Florida, United States

Sree Sindhu Vijayarao, MBBS

• Maqbool, Farkhanda, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan

Farkhanda Maqbool

• Patel, Divya, Gujarat Medical Education and Research Society, Gandhinagar, GJ, India

Divya Patel, MD

• Kuraku, Dileep Raja, Vinnic'kij nacional'nij medicnij universitet imeni Mikoli Pirogova, Vinnytsia, Vinnytsia Oblast, Ukraine

Dileep Raja Kuraku, MD

• Keshapogu, Nagarjuna, Vinnic'kij nacional'nij medicnij universitet imeni Mikoli Pirogova, Vinnytsia, Vinnytsia Oblast, Ukraine

Nagarjuna Keshapogu, MD

• Thiyagarajan, Ragav Vikraman, MAHSA University, Federal Territory of Kuala Lumpur, Malaysia

Ragav Vikraman Thiyagarajan, MBBS

• Attaluri, Durga Manaswini, Sri Aurobindo Institute of Medical Sciences, Indore, MP, India

Durga Manaswini Attaluri, MD

• Venkatesh, Karthik Kanna, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, PY, India

Karthik Kanna Venkatesh, MBBS

• Narla, Sai Jahnu Sree Reddy, Paris Regional Medical Center, Paris, Texas, United States

Sai Jahnu Sree Reddy Narla, MD

• Khan, Nabiha, Faisalabad Medical University, Faisalabad, Punjab, Pakistan

Nabiha Khan, MBBS

• Younas, Kashf, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan

Kashf Younas

• Tekuru, Yogesh, Saint Louis University, St. Louis, Missouri, United States

Yogesh Tekuru, MBBS, MPH

• Vemulapalli, Sai Charan, Our Lady of Fatima University, Valenzuela, NCR, Philippines

Sai Charan Vemulapalli, MD

• Kalluri, Hara Gopal, Saint Martinus University Faculty of Medicine, Willemstad, Curaçao

Hara Gopal Kalluri

• Maqbool, Tehmeena, Bakhtawar Amin Medical and Dental College, Multan, Punjab, Pakistan

Tehmeena Maqbool

Background

Renal failure and Malignant neoplasms are leading causes of premature death worldwide. Their coexistence worsens outcomes, yet population-level mortality trends remain underexplored. This study examines temporal disparities in U.S. mortality from 1999 to 2024.

Methods

We conducted a retrospective CDC WONDER analysis (1999–2024) using ICD-10 codes N17-N19 (Renal Failure) followed by C00-C97( Malignant Neoplasms). Age-adjusted mortality rates (AAMR) were stratified by sex, race, census region, and urbanization. Joinpoint regression calculated Annual Percent Change (APC) and Average Annual Percent Change (AAPC) with p<0.05.

Results

Overall mortality rate rose from 10.27 in 1999 to 12.03 in 2024 with 623,696 deaths. The rate increased non-significantly from 1999–2012 (APC: 0.54, 95% CI: -0.30–1.39), then non-significantly declined from 2012–2016 (APC: -6.91, 95% CI: -14.01–0.79), then significantly rise from 2016–2024 (APC: 4.53*, 95% CI: 2.93–6.15; p<0.001). Mortality was higher in males (15.73) than females (9.29) in 2024. The highest AAMR was among Black populations (18.99, 95% CI: 18.49–19.50), followed by Whites (11.54, 95% CI: 11.40–11.68). Rates peaked at age ≥85 years (100.34). The West had the highest rate (13.11, 95% CI: 12.81–13.40), followed by the South (12.55, 95% CI: 12.27–12.83). AAMR was highest in Non-Core areas (10.82 , 95% CI: 10.34–11.29), followed by Small Metro areas (9.34 , 95% CI: 8.96–9.72).

Conclusion

This study reveals critical research gaps in renal failure and malignant neoplasms mortality trends across age, race, and geography. Urgent, equity-focused prevention strategies are required to dismantle persistent disparities.