Abstract: TH-PO0708
Rising Burden of Cardiac Arrest as a Cause of Death in Patients with Kidney Failure, 1999-2024: A Nationwide Centers for Disease Control and Prevention (CDC)-Based Analysis
Session Information
- AKI: Prevention, Diagnostics, and Management
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Acute Kidney Injury
- 101 AKI: Epidemiology, Risk Factors, and Prevention
Authors
- Ul Abideen, Zain, Sheikh Zayed Hospital, Rahim Yar Khan, Punjab, Pakistan
- Sheikh, Maryam Imran, Riphah International University, Islamabad, Islamabad Capital Territory, Pakistan
- Sameer, Muhammad, Sheikh Zayed Hospital, Rahim Yar Khan, Punjab, Pakistan
- Qasim, Sheraz, Post Graduate Medical Institute Ameer-ud-Din Medical College, Lahore, Punjab, Pakistan
- Kiwan, Mezhgan, Gomal Medical College, Dera Ismail Khan, N.W.F.P, Pakistan
- Sheikh, Abdullah Muhammad, Jinnah Medical and Dental College, Karachi, Sindh, Pakistan
- Shaikh, Fiza, Peoples University of Medical and Health Sciences for Women, Nawabshah, Sindh, Pakistan
- Usman, Muhammad Talha, Gajju Khan Medical College Swabi, Swabi, N.W.F.P, Pakistan
- Shahid, Samia, Foundation University Islamabad, Islamabad, Islamabad Capital Territory, Pakistan
- Zaheer, Hamza, Lahore General Hospital, Lahore, Punjab, Pakistan
- Nawaz, Muhammad Shahmir, Lahore General Hospital, Lahore, Punjab, Pakistan
Background
Cardiac arrest (CA) is a common terminal cardiovascular event among patients with renal failure (RF) and accounts for nearly 25% of deaths in patients with chronic kidney disease. CA contributes substantially to mortality in this population. We aimed to evaluate temporal trends in mortality among U.S. adults with coexisting CA and RF.
Methods
Data were extracted from the CDC WONDER database for cardiac arrest ((ICD-10 CODE I46) and renal failure (ICD-10 CODE N17-N19) form 1999–2024. Age-adjusted mortality rates (AAMRs) per 100,000 population and annual percentage changes (APCs) with 95% confidence intervals (CIs) were calculated. Temporal mortality trends were analyzed using joinpoint regression and stratified by age, sex, ethnicity, geographic region (census regions), and urbanization status.
Results
Between 1999 and 2024, 159,694 RF- and CA-related deaths were reported (AAPC −1.3%), with higher mortality among males. In males, mortality increased from 2019–2022 (APC +2.6%) before sharply declining during 2022–2024 (APC −7.5%). Hispanics consistently showed higher AAMRs than non-Hispanics, with stable trends throughout the study period (APC −1.4%). Blacks had the highest mortality, followed by Asians (AAPC −1.9%) and Whites (AAPC −1.0%). Among Blacks, mortality declined from 1999–2017 (APC −2.2%), with a sharper decrease during 2021–2024 (APC −6.2%). Mortality rates varied significantly across region with highest rates reported among Northeast (AAPC -1.6%) followed by South (AAPC -2.2%) and West (AAPC +0.5%). Mortality rates were consistently higher in urban regions compared with rural regions throughout the study period.
Conclusion
RF- and CA-related mortality declined significantly throughout the study period. However, substantial disparities persisted, with the highest mortality rates observed among males, Hispanics, African Americans, and residents of the Northeastern and metropolitan United States. Targeted preventive and therapeutic strategies are needed to reduce the burden of CA among patients with RF and further decrease RF- and CA-related mortality.