Abstract: TH-PO0881
Super High-Flux Hemodialysis vs. High-Flux Hemodialysis in an Ecuadorian Dialysis Population
Session Information
- Dialysis: Prescription, Physiology, and Treatment Optimization
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Dorta, Antonio, International Society of Nephrology, Brussels, Belgium
- Borges, Mariant Jenifer, Corporacion Integral de Dialisis, Quito, Ecuador
Background
Retention of medium molecular weight toxins appears to influence the course and quality of life of patients on conventional hemodialysis. The objective is to compare clinical parameters, body composition, quality of life, and clearance parameters of patients on high-flux hemodialysis (HF-HD) and super high flux hemodialysis (SHF-HD).
Methods
Experimental, randomized, controlled, crossover study. Patients were selected from the Centro Integral de Diálisis Renacer in Portoviejo, Manabí, Ecuador, in January 2025. One group was treated for 6 months with HF-HD, followed by SHF-HD for another 6 months, while the other group underwent the opposite sequence. IBM SPSS version 25.0 was used. Descriptive statistics and the t-test for differences (final – initial) were employed.
Results
159 patients were studied; most were over 40 years old (90.6%) and male (65.4%). An improvement in overall quality of life was found for SHF-HD (differences final – initial, HF-HD vs. SHF-HD) (-1.49 vs. 2.84), especially in the domains of general health, disease burden and effects, and symptoms/problems, as well as a decrease in PTH concentrations (64.96 vs. -52.05 pg/ml), mean CRP (1.99 vs. -2.39 mg/l) and mean fat mass by bioimpedance (-0.75 vs. -1.93 kg), and an increase in mean serum iron (3.21 vs. 12.09 µg/dl).
Conclusion
Switching from HF-HD to SHF-HD leads to increased perceived quality of life and serum iron levels, as well as decreased PTH, CRP, and fat mass.