Kidney Week

Abstract: SA-PO0307

Trends in AKI-Related Mortality in Postmenopausal Women in the United States, 1999-2024

Session Information

• AKI: Epidemiology and Risk Factors
  October 24, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Acute Kidney Injury

• 101 AKI: Epidemiology, Risk Factors, and Prevention

Authors

• Premkumar, Chandra Rupini, Government Kilpauk Medical College and Hospital, Chennai, TN, India

Chandra Rupini Premkumar, MBBS

• Mahrukh, Fnu, University Medical and Dental College Faisalabad, Faisalabad, Punjab, Pakistan

Fnu Mahrukh

• Chaudhary, Arishman Yasin, University Medical and Dental College Faisalabad, Faisalabad, Punjab, Pakistan

Arishman Yasin Chaudhary

• Attiq, Zainab, University Medical and Dental College Faisalabad, Faisalabad, Punjab, Pakistan

Zainab Attiq, MBBS

• Zafar, Sahar, University Medical and Dental College Faisalabad, Faisalabad, Punjab, Pakistan

Sahar Zafar, MBBS

• Zahid, Wareesha, University Medical and Dental College Faisalabad, Faisalabad, Punjab, Pakistan

Wareesha Zahid, MBBS

• Kashif, Shiza, University Medical and Dental College Faisalabad, Faisalabad, Punjab, Pakistan

Shiza Kashif

• Rasheed Sohail, Shehryar, Jinnah Sindh Medical University, Karachi, Sindh, Pakistan

Shehryar Rasheed Sohail

Background

Post-menopausal women are at a higher risk of acute kidney injury (AKI) as compared to pre-menopausal women due to an increased propensity to gynaecological causes of post-renal AKI such as ovarian disorders, uterovaginal prolapse, and major inpatient gynaecological surgeries. We aim to define epidemiological differences in the United States (U.S.) due to AKI-related mortality in post-menopausal women using the CDC-WONDER database over the decades.

Methods

CDC WONDER was used to analyze mortality trends due to AKI (ICD-10 code N17) in post-menopausal women (≥55 years) from 1999-2024. Age-adjusted mortality rates (AAMR) per 100,000 population were calculated. Annual percent change (APC) and average annual percent change (AAPC) with 95% confidence intervals were assessed using the Joinpoint Regression Program to stratify trends.

Results

From 1999-2024, a total of 730,458 deaths were recorded. From 1999-2024, overall AAMR rose significantly from 38.9 in 1999 to 86.52 in 2024 (AAPC: 3.05; 95% CI 2.79 to 3.38). Stratified by age, the 55-64 age group showed the highest trend in mortality (AAPC: 4.55; 95% CI: 3.93 to 5.28). Non-Hispanic women (AAPC: 3.12; 95% CI: 2.86 to 3.43) showed a greater rise in mortality than Hispanic women (AAPC: 2.90; 95% CI: 2.25 to 4.10). Amongst non-Hispanic women, White patients showed the highest mortality rate (AAPC: 3.27; 95% CI: 2.99 to 3.57). Additionally, rural areas consistently showed greater crude mortality rates than urban areas (AAPC: 2.99% vs 1.36%).

Conclusion

Regional and demographic disparities in AKI-related mortality in post-menopausal women indicate the need for prompt gender-specific intervention and research for kidney health