Abstract: FR-PO0262
Lipid Profile and Risk of Hospitalization with Infection in Patients with CKD: The CRIC Study
Session Information
- CKD: Omics, Systemic Stressors, and Targeted Pharmacotherapy
October 23, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: CKD (Non-Dialysis)
- 2201 CKD (Non-Dialysis): Epidemiology, Risk Factors, and Prevention
Authors
- Srivastava, Saloni, Mass General Brigham Inc, Boston, Massachusetts, United States
- Ishigami, Junichi, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States
- Matsushita, Kunihiro, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States
- Appel, Lawrence J., Johns Hopkins Medicine, Baltimore, Maryland, United States
Background
Acute infections are an important complication of CKD. Dysregulated lipid metabolism in CKD may impair immune pathways and exacerbate susceptibility to infection beyond the contribution attributable to CKD itself. The aim was to analyze the association of lipid profiles with the risk of hospitalization with infection in people with CKD.
Methods
We analyzed 3,927 participants to examine the association of lipid measures (HDL-C, Triglycerides, Apolipoprotein A1 and Apolipoprotein B) with time to first hospitalization with infection, ascertained on ICD codes for infections on discharge records [e.g. respiratory tract infections, sepsis]. Lipid measures were grouped into quartiles and also modeled as continuous variables using restricted cubic spline terms. Multivariable Cox proportional hazards models were used to estimate hazard ratios.
Results
During follow-up, 74.2% had hospitalization with infection (incidence rate, 28.9 per 1,000 person-years). In Multivariable Cox models, TG was significantly associated with the risk of hospitalization with infection (Q3 vs Q1 HR 1.19, 95% CI 1.04-1.35). In a restricted cubic spline model, inflection points were observed at HDL-C <40 mg/dL and TG >150 mg/dL, where the risk of infection increased. The cross-category analysis of HDL-C and TG suggested a multiplicative effect without a significant interaction (p-for-interaction, >0.05). Associations were not significant for ApoA1 and ApoB in either crude or multivariable models.
Conclusion
Among people with CKD, lower HDL-C and higher TG levels were associated with an increased risk of infection, with apparent inflection points consistent with clinical thresholds (HDL-C <40 mg/dL and TG >150 mg/dL). Whether lipid management targeting HDL-C and TG levels could modify infection risk warrants further investigation.
Restricted cubic spline models for HDL-C, TG, ApoA1, and ApoB.
Funding
- NIDDK Support