Kidney Week

Abstract: FR-PO0978

Global Trends and Regional Disparities in CKD Among Women Attributable to Metabolic Risks, 1990-2023

Session Information

• Women's Health and Kidney Diseases
  October 23, 2026 | Location: Exhibit Hall A, Convention Center
  Abstract Time: 10:00 AM - 12:00 PM

Category: Women's Health and Kidney Diseases

• 2100 Women's Health and Kidney Diseases

Authors

• Seth, Sukriti, University of Central Florida College of Medicine/HCA Healthcare GME Consortium, Ocala, Florida, United States

Sukriti Seth, MBBS

• Kodali, Naga Anvesh, University of Central Florida College of Medicine/HCA Healthcare GME Consortium, Ocala, Florida, United States

Naga Anvesh Kodali, MD, MBBS

• Desai, Hardik, AB Plus Multispecialty Hospital, Ahmedabad, Gujarat, India

Hardik Desai, MBBS

• Vaghela, Mahesh K., University of Central Florida College of Medicine/HCA Healthcare GME Consortium, Ocala, Florida, United States

Mahesh K. Vaghela, MD, FASN

Background

Metabolic risks are major modifiable drivers of chronic kidney disease (CKD), but their female-specific global contribution remains underdefined.

Methods

We analyzed Global Burden of Disease 1990–2023 estimates for females with CKD attributable to metabolic risks. Outcomes included DALYs, deaths, YLLs, YLDs, and age-standardized DALY/death rates. Percent change and annualized percentage change (APC) were calculated.

Results

Globally, female CKD DALYs attributable to metabolic risks increased from 10.27 million in 1990 to 22.02 million in 2023 (+114.4%; APC +2.34%/year). Deaths increased from 281,026 to 749,251 (+166.6%; APC +3.02%/year). YLLs rose from 8.09 to 16.87 million (+108.6%), while YLDs increased from 2.19 to 5.16 million (+135.9%). The age-standardized DALY rate increased modestly from 450.6 to 475.7 per 100,000 (+5.6%; APC +0.16%/year), and the age-standardized death rate rose from 13.4 to 15.3 per 100,000 (+13.8%; APC +0.39%/year). By age, DALY rates declined among females <20 years (114.0 to 93.4 per 100,000; -18.1%) but increased in ages 20–54 years (311.0 to 356.8; +14.7%) and ≥55 years (1472.6 to 1685.1; +14.4%). Among specific metabolic risks, high BMI showed the steepest DALY rise (+291.4%; APC +4.22%/year), followed by high fasting plasma glucose (+198.9%; +3.37%/year) and high systolic blood pressure (+171.5%; +3.07%/year). In 2023, the highest regional age-standardized DALY rates occurred in North Africa and the Middle East (888.6), Sub-Saharan Africa (883.7), and Latin America and the Caribbean (745.1) per 100,000.

Conclusion

Metabolic-risk-attributable CKD burden in women more than doubled, driven by deaths and older-adult DALYs. Prevention targeting obesity, dysglycemia, and hypertension is essential.