Abstract: TH-PO0874
Hemodynamic and Biochemical Factors Associated with Late Weaning from CRRT in Patients with KDIGO Stage 3 AKI
Session Information
- Dialysis: Prescription, Physiology, and Treatment Optimization
October 22, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Dialysis
- 801 Dialysis: Hemodialysis and Frequent Dialysis
Authors
- Vazquéz Martínez, Maria de los Ángeles, Instituto Mexicano del Seguro Social, Mexico City, CDMX, Mexico
- Paniagua, Ramón, Instituto Mexicano del Seguro Social, Mexico City, CDMX, Mexico
- Cuevas Budhart, Miguel Angel, Instituto Mexicano del Seguro Social, Mexico City, CDMX, Mexico
- Silva, Rogelio, Instituto Mexicano del Seguro Social, Mexico City, CDMX, Mexico
Background
The requiring continuous renal replacement therapy (CRRT) in Acute kidney injury KDIGO 3 is associated with high morbidity and mortality in critically ill patients. However, factors associated with weaning fail remain insufficiently characterized.
Objective: To identify hemodynamic, biochemical, and clinical factors associated with weaning failure CRRT in critically ill patients with AKI
Methods
Prospective observational cohort study including critically ill adults with KDIGO stage 3 AKI treated with CRRT at a tertiary referral center in Mexico. Demographic, hemodynamic, biochemical, and renal variables were collected during therapy, expose in table 1. Prolonged CRRT was defined as therapy duration ≥72 hours. Comparative inferential analyses were performed according to CRRT duration.
Results
Forty patients were included. Mean age was 60.8 ± 16.3 years, and median hospital stay was 23 days. Sepsis associated with AKI was the predominant etiology. Compared with patients receiving non prolonged CRRT, the prolonged CRRT group showed higher SOFA scores [12 (7,15) vs 7 (6,10), p=0.01], higher initial lactate levels [4.6 (2.3,7.8) vs 1.8 (1.2,3.1) mmol/L, p=0.02], more positive global fluid balance (7800 ± 2600 vs 4500 ± 1800 mL, p=0.01), greater vasopressor requirement (81% vs 40%, p=0.01), and lower initial urine output [30 (0,100) vs 220 (50,500) mL, p=0.004]. Sepsis associated with AKI and preexisting chronic kidney disease were also associated with prolonged therapy.
Conclusion
Prolonged CRRT was associated with greater hemodynamic instability, higher organ dysfunction burden, positive fluid balance, reduced urine output, and sepsis associated AKI. Early identification of high risk phenotypes may optimize CRRT management in critically ill patients.