Abstract: SA-PO0860
Complications and Risk Factors After Native Kidney Biopsy in Patients with Reduced Kidney Function
Session Information
- Glomerular Diseases: Management, Evolving Strategies, and Practice-Changing Advances
October 24, 2026 | Location: Exhibit Hall A, Convention Center
Abstract Time: 10:00 AM - 12:00 PM
Category: Glomerular Diseases
- 1402 Glomerular Diseases: Clinical, Outcomes, and Therapeutics
Authors
- Ortuño Moreno, Nohelia María, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
- Garcia-Flores, Octavio Rene, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
- Barrientos Feria, Sarai Ruth, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
- Vasquez, Enzo, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
- Salgado González, Francisco Gabriel, Hospital Juarez de Mexico, Mexico City, CDMX, Mexico
Background
Kidney biopsy is an essential diagnostic procedure in nephrology because it provides definitive histopathological information for diagnosis and treatment decisions. Despite its utility, it carries an inherent risk of complications, particularly in patients with impaired kidney function. Data regarding post-biopsy complications in Latin American populations remain limited. We aimed to describe complication rates and associated risk factors after native kidney biopsy.
Methods
We conducted a retrospective observational study including 200 patients who underwent ultrasound-guided native kidney biopsy. Major complications were defined as transfusion, embolization, nephrectomy, surgical drainage, or death. Risk factors analyzed included blood urea nitrogen >90 mg/dL, hemoglobin <10 g/dL, platelet count, blood pressure, pre-biopsy hemodialysis, and estimated glomerular filtration rate (eGFR) using CKD-EPI. Statistical analysis included descriptive statistics and multivariable logistic regression.
Results
Mean age was 41 ± 15 years and 54% were female. Diabetes was present in 18%, systemic lupus erythematosus in 32 %, and HIV infection in 3%. Overall complications occurred in 10% of patients, mainly hematuria and perirenal hematomas, while major complications occurred in 1.5%, without biopsy-related deaths. Hemoglobin <10 g/dL (OR 2.5, 95% CI 1.2–5.3, p=0.01) and eGFR <30 ml/min/1.73 m2 (OR 2.2, 95% CI 1.1–4.6, p=0.03) were independently associated with higher complication risk. Complication frequency increased progressively from 4.5% in CKD G1–G2 to 18% in G4–G5. Lupus nephritis was the most frequent diagnosis, followed by diabetic kidney disease and focal segmental glomerulosclerosis. ANCA-associated vasculitis was also associated with increased complication risk.
Conclusion
Lower eGFR was associated with progressively higher post-biopsy complication rates. Advanced CKD, anemia, and ANCA-associated vasculitis emerged as the main predictors of adverse events, supporting hemoglobin optimization, risk stratification, and closer monitoring in patients with eGFR <30 ml/min.
Funding
- Government Support – Non-U.S.